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| Cas No.: | 256476-36-5 |
| Chemical Name: | 2-((4-chloro-1-((diaminomethylene)amino)isoquinoline)-7-sulfonamido)-2-methylpropanoic acid |
| Synonyms: | UK371804,UK 371804 |
| SMILES: | CC(C)(NS(=O)(C1=CC2=C(C=C1)C(Cl)=CN=C2/N=C(N)\N)=O)C(O)=O.HCl |
| Formula: | C14H16ClN5O4S.HCl |
| M.Wt: | 422.29 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | UK-371804 is a potent and selective uPA inhibitor with excellent enzyme potency (Ki 10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin). In vitro, UK-371804 is able to inhibit exogenous uPA in human chronic wound fluid (IC50=0.89 microM). In vivo, in a porcine acute excisional wound model, following topical delivery, UK-371804 is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters. UK-371804 was selected as a candidate for further preclinical evaluation for the treatment of chronic dermal ulcers. |