UNC569|UNC 569|Mer receptor tyrosine kinase(RTK) Inhibitor

Cas No.:	1350547-65-7
Chemical Name:	1-(((1r,4r)-4-aminocyclohexyl)methyl)-N-butyl-3-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine
Synonyms:	UNC-569，UNC 569
SMILES:	FC1=CC=C(C2=NN(C[C@H]3CC[C@H](N)CC3)C4=NC(NCCCC)=NC=C42)C=C1
Formula:	C₂₂H₂₉FN₆
M.Wt:	396.5
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

UNC569 is a novel small-molecule MER inhibitor with efficacy against acute lymphoblastic leukemia in vitro and in vivo.

Cat. No.	Product name	Field of application
DC11689	RU-301	RU-301 (RU301) is a small molecule pan-TAM inhibitor that targets the TAM Ig1-Gas6 interface, blocks Gas6-dependent TAM activation.
DC10127	UNC569	UNC569 is a novel small-molecule MER inhibitor with efficacy against acute lymphoblastic leukemia in vitro and in vivo.
DC7931	UNC2025	UNC2025 is a potent and orally bioavailable Mer/Flt3 dual inhibitor with IC50 of 0.8/0.74 nM for Mer/Flt3.
DC9289	UNC-2025 HCl	UNC-2025 is a potent and orally bioavailable dual MER/FLT3 inhibitor with IC50 of 0.74 nM and 0.8 nM, respectively, about 20-fold selectivity over Axl and Tyro3.
DC8223	TP-0903	TP-0903 is a a high-affinity Axl inhibitor with IC50 of 27 nM.
DC8535	SGI-7079	SGI-7079 is a novel Axl inhibitor.
DC10071	S49076	S49076 is a novel, potent inhibitor of MET, AXL/MER, and FGFR1/2/3 with IC50 values below 20 nM.
DC11265	S49076 (hydrochloride)	S49076 is a novel kinase inhibitor of MET, AXL, and FGFR with strong preclinical activity alone and in association with bevacizumab.