UNC6852|CAS 2688842-08-0|DC Chemicals

Cas No.:	2688842-08-0
Chemical Name:	UNC6852
Synonyms:	UNC6852;CHEMBL4749741;(2S,4R)-1-((S)-2-(4-(4-(5-((Furan-2-ylmethyl)amino)-[1,2,4]triazolo[4,3-c]pyrimidin-8-yl)benzamido)butanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;G17406;BDBM50562612;EN300-33291358;Z4761635064;SCHEMBL25071327;EX-A3973;(2S,4R)-1-[(2S)-2-(4-{[4-(5-{[(furan-2-yl)methyl]amino}-[1,2,4]triazolo[4,3-c]pyrimidin-8-yl)phenyl]formamido}butanamido)-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide;(2S,4R)-1-[(2S)-2-[4-[[4-[5-(furan-2-ylmethylamino)-[1,2,4]triazolo[4,3-c]pyrimidin-8-yl]benzoyl]amino]butanoylamino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide;2688842-08-0;CS-0112131;MS-31550;HY-130708,UNC-6852
SMILES:	O1C=CC=C1CNC1N2C=NN=C2C(C2C=CC(C(NCCCC(=O)N[C@@H](C(C)(C)C)C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3C=CC(=CC=3)C3SC=NC=3C)=O)=CC=2)=CN=1
Formula:	C₄₃H₄₈N₁₀O₆S
M.Wt:	832.97
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	[1]. Potjewyd F, et al. Degradation of Polycomb Repressive Complex 2 with an EED-Targeted Bivalent Chemical Degrader. Cell Chem Biol. 2020 Jan 16;27(1):47-56.e15.

Cat. No.	Product name	Field of application
DC28688	UNC6852	UNC6852 is a selective rolycomb repressive complex 2 (PRC2) degrader based on PROTAC and contains an EED (embryonic ectoderm development) ligand and a VHL ligand, with an IC50 of 247 nM for EED.