VU6012962|mGlu7 negative allosteric modulator

Cas No.:
Chemical Name:	N-(2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethoxy)phenyl)-4-(cyclopropylmethoxy)-3-methoxybenzamide
Synonyms:	VU6012962，VU-6012962，VU 6012962
SMILES:	O=C(C1=CC=C(OCC2CC2)C(OC)=C1)NC3=C(N4C=NC=N4)C=CC(OC(F)(F)F)=C3
Formula:	C₂₁H₁₉F₃N₄O₄
M.Wt:	448.402
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

VU6012962 (VU-6012962) is a potent, orally bioavailable and CNS penetrant mGlu7 negative allosteric modulator with IC50 of 0.35 uM; VU6012962 is highly selective for mGlu7 versus the other seven mGlu receptor subtypes and across large ancillary pharmacology panels; decreases anxiety in the elevated zero maze (EZM) assay in mice.

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