Valbenazine(NBI-98854)|VMAT2 inhibitor

Cas No.:	1025504-45-3
Chemical Name:	(2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-yl L-valinate
Synonyms:	NBI-98854; NBI 98854; NBI98854; MT-5199; MT 5199; MT5199; Valbenazine; Ingrezza;
SMILES:	N[C@@H](C(C)C)C(O[C@H]1[C@H](CC(C)C)CN2CCC3=CC(OC)=C(OC)C=C3[C@@]2([H])C1)=O
Formula:	C₂₄H₃₈N₂O₄
M.Wt:	418.578
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	Valbenazine is a prodrug of the (+)-α isomer of tetrabenazine for tardive syndrome therapy, and inhibits VMAT2 function.
In Vivo:	Valbenazine shows a distinctive improvement in tardive dyskinesia symptoms during the successful Phase II trial[1].
References:	[1]. Müller T, et al. Valbenazine granted breakthrough drug status for treating tardive dyskinesia. Expert Opin Investig Drugs. 2015 Jun;24(6):737-42.

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Valbenazine（NBI-98854）