YL-0919|YL0919|5-HT1A Receptor Agonist

Cas No.:	1339058-04-6
Synonyms:	YL0919 ,YL 0919
SMILES:	C1C=CC=CC=1CN1CCC(O)(CN2C(=O)C=CC=C2)CC1.Cl
Formula:	C₁₈H₂₃ClN₂O₂
M.Wt:	334.84
Purity:	>98%
Sotrage:	4°C for 1 year, -20°C for more than 2 years

Description:	YL0919, a novel antidepressant candidate with dual activity as a 5-HT1A receptor agonist and a selective serotonin reuptake inhibitor,the IC50 values of YL-0919 inhibiting the uptake of 5-HT into rat cerebral cortical synaptosomes and human recombinant cells were 1.78±0.34 nM and 1.93±0.18 nM respectively.
Target:	target: 5-HT1A receptor IC50:1.78±0.34 nM(rat cerebral cortical synaptosomes) IC50:1.93±0.18 nM(human recombinant cells)[1]
In Vitro:	WAY-100635 completely antagonized the antidepressant-like activity of YL-0919 in both behavioral models, suggesting that activation of the 5-HT1A receptor is critical in the antidepressant-like effect of YL-0919. The administered dose of WAY-100635 ranged from 0.1–0.3 mg/kg, which reportedly has no effect on locomotor activity and only blocks the activation of 5-HT1A receptor.[2]
References:	[1]. Chen, H. X. et al. Antidepressant-like activity of YL-0919: a novel combined selective serotonin reuptake inhibitor and 5-HT1A receptor agonist. PloS one 8, e83271, doi:10.1371/journal.pone.0083271 (2013). [2]. Qin, J. J. et al. The role of activation of the 5-HT1A receptor and adenylate cyclase in the antidepressant-like effect of YL-0919, a dual 5-HT1A agonist and selective serotonin reuptake inhibitor. Neuroscience letters 582, 104-108, 2014.09.009 (2014)

Cat. No.	Product name	Field of application
DC8755	WAY 100635 Hydrochloride
DC9932	YL-0919	YL-0919 is a novel synthetic compound with combined high affinity and selectivity for serotonin transporter and 5-HT1A receptors.
DC8288	Vortioxetine hydrobromide	Vortioxetine Hcl (Lu AA21004 Hcl) is a multimodal serotonergic agent, inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT with IC50 of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively.
DC8613	Vortioxetine (Lu AA21004)	Vortioxetine (Lu AA21004) is a multimodal serotonergic agent, inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT with IC50 of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively.
DC8354	Intepirdine (SB-742457, RVT-101）	SB-742457(RVT-101) is a selective 5-HT6 receptor antagonist with potential cognition, memory, and learning-enhancing effects.
DC8483	SB-399885 HCl	Potent, brain penetrant, orally active 5-HT6 antagonist. Displays > 200-fold selectivity for 5-HT6 over other 5-HT receptors (pKi values are 9.11, 8.81 and 9.02 for human recombinant, native rat and native human 5-HT6 receptors respectively).
DC4102	SB-269970,SB 269970	SB269970 is a potent and selective 5-HT7 receptor antagonist.
DC9313	Sarpogrelate (hydrochloride)	Sarpogrelate(MCI-9042) hydrochloride, a selective 5-HT2 antagonist, has been widely used as an anti-platelet agent for the treatment of PAD.
DC8334	RS-127445	RS-127445 is a potent and selective antagonist at the serotonin 5-HT2B receptor, with around 1000x selectivity over the closely related 5-HT2A and 5-HT2C receptors.
DC9322	Ramosetron (Hydrochloride)	Ramosetron Hydrochloride(YM060 Hydrochloride) is a serotonin 5-HT3 receptor antagonist for the treatment of nausea and vomiting.