AZD5069|AZD-5069|cas 878385-84-3|DC Chemicals

Cas No.:	878385-84-3
Chemical Name:	N-(2-((2,3-difluorobenzyl)thio)-6-(((2R,3S)-3,4-dihydroxybutan-2-yl)oxy)pyrimidin-4-yl)azetidine-1-sulfonamide
Synonyms:	AZD-5069; AZD 5069; AZD5069,878385-84-3
SMILES:	O=S(N1CCC1)(NC2=NC(SCC3=CC=CC(F)=C3F)=NC(O[C@H](C)[C@@H](O)CO)=C2)=O
Formula:	C₁₈H₂₂F₂N₄O₅S₂
M.Wt:	476.51
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	AZD-5069 is a potent CXCR2 chemokine receptor antagonist, used for caner treatment.
Target:	125I-IL-8-CXCR2
In Vitro:	AZD-5069 (Compound 2) acts as CXCR2 antagonist by inhibition of [125I]-IL-8 binding to human CXCR2 receptors and as inhibitor of GROα-induced Ca2+ flux in human neutrophils loaded with fluo-3 dye[1].
References:	[1]. Norman P. Evidence on the identity of the CXCR2 antagonist AZD-5069. Expert Opin Ther Pat. 2013 Jan;23(1):113-7.

Cat. No.	Product name	Field of application
DC10773	AZD5069	AZD-5069 is a potent and selective CXCR2 antagonist with the potential to inhibit neutrophil migration into the airways in patients with COPD.