gamma-Secretase Modulators|CAS 937812-80-1|DC Chemicals

Cas No.:	937812-80-1
Chemical Name:	gamma-Secretase Modulators
SMILES:	O=C1N2[C@@H](COC[C@]2([H])CC/C1=C\C3=CC(OC)=C(C=C3)N4C=NC(C)=C4)C5=CC(F)=C(F)C(F)=C5
Formula:	C₂₆H₂₄F₃N₃O₃
M.Wt:	483.48
Sotrage:	4°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Cat. No.	Product name	Field of application
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DC46940	AZD4694	AZD4694, a fluorinated β-amyloid (Aβ) plaque neuroimaging PET radioligand, shows high affinity for Aβ fibrils (Kd = 2.3 nM).
DC46641	Methyl tridecanoate	Methyl tridecanoate moderately inhibits β-amyloid aggregation. Methyl tridecanoate weakly inhibits acetylcholinesterase (AChE).
DC45833	Aβ/tau aggregation-IN-1	Aβ/tau aggregation-IN-1 is a potent Aβ1-42 β-sheets formation and tau aggregation inhibitor. The KD values of Aβ/tau aggregation-IN-1 with Aβ1-42 and tau are 160 μM and 337 μM, respectively. Aβ/tau aggregation-IN-1 can permeate the blood-brain barrier.
DC45771	RAGE antagonist peptide TFA	RAGE antagonist peptide TFA is an advanced glycation end products (RAGE) antagonist. RAGE antagonist peptide TFA prevents RAGE from binding with several of its most important ligands, including HMGB-1, S100P, and S100A4. RAGE antagonist peptide TFA possesses anti-tumor and anti-inflammatory activities.
DC44797	Cl-NQTrp	Cl-NQTrp signifcantly disrupts the preformed fbrillar aggregates of Tau-derived PHF6 (VQIVYK) peptide and full-length tau protein.
DC44796	Beta-Amyloid(1-14),mouse,rat	Beta-Amyloid(1-14),mouse,rat is a 1 to 14 fragment of Amyloid-β peptide.
DC44795	β-Amyloid (22-40)	β-Amyloid (22-40) is a peptide fragment of β-Amyloid.
DC44794	β-Amyloid (11-22)	β-Amyloid (11-22) is a peptide fragment of β-Amyloid.
DC42447	gamma-Secretase Modulators	gamma-Secretase Modulators (Amyloid-β production) is a Amyloid-β production.