IRAK-4 protein kinase inhibitor 2|CAS 301675-24-1|DC Chemicals

Cas No.:	301675-24-1
Synonyms:	IRAK-4 protein kinase inhibitor 2
SMILES:	O=C(NC1=NC2=CC=CC=C2N1)C3=CC=CC([N+]([O-])=O)=C3
Formula:	C₁₄H₁₀N₄O₃
M.Wt:	282.25
Sotrage:	Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month

Cat. No.	Product name	Field of application
DC46171	PROTAC IRAK4 degrader-5	PROTAC IRAK4 degrader-5 is a PROTAC-based IRAK4 degrader extracted from patent US20190192668A1, compound I-171.
DC42505	IRAK-4 protein kinase inhibitor 2	IRAK-4 protein kinase inhibitor 2 (compound 1) is a potent inhibitor of interleukin-1 (IL-1) receptor-associated kinase-4 (IRAK-4), with an IC50 of 4 μM. IRAK-4 protein kinase inhibitor 2 can be used for the research of inflammatory and immune-related conditions or disorders.
DC42322	HS271	HS271 is a highly potent, orally active and selective IRAK4, with an IC50 of 7.2 μM. HS271 exhibits superior enzymatic and cellular activities, as well as excellent pharmacokinetic properties.
DC40577	IRAK inhibitor 4	IRAK inhibitor 4 is an interleukin-1 receptor associated kinase 4(IRAK4) inhibitor.
DC40037	JH-X-119-01 hydrochloride	JH-X-119-01 hydrochloride is a potent and selective interleukin-1 receptor-associated kinases 1 (IRAK1) inhibitor. JH-X-119-01 hydrochloride ameliorates LPS-induced sepsis in mice.
DC28331	IRAK4-IN-4	IRAK4-IN-4 is an interleukin-1 receptor–associated kinase 4 (IRAK4) inhibitor extracted from patent CN107163044A, Compound15, has an IC50 of 2.8 nM. IRAK4-IN-4 also inhibits cyclic GMP-AMP synthase (cGAS) with an IC50 of 2.1 nM.
DC11185	PF-06426779	PF-06426779 (PF06426779) is a potent, selective IRAK4 inhibitor with IC50 of 1 nM against full-length IRAK4 kinase and cell-based IC50 of 12 nM.
DC9492	IRAK inhibitor 2	IRAK inhibitor 2 is interleukin-1 receptor associated kinase inhibitor .
DC11497	IRAK4-IN-28	A novel potent, selective IRAK4 inhibitor with IC50 of 51 nM.