KWR137|CAS |DC Chemicals

Cas No.:
Chemical Name:	KWR137
SMILES:	ClC1=CC(C(F)(F)F)=CC=C1NC(CN2C(CC)=C(N3CCN(C(C(N4)=CC5=C4C=CC=N5)=O)CC3)C(N6C2=NC(C7=CCOCC7)=N6)=O)=O
Formula:	C₃₃H₃₁ClF₃N₉O₄
M.Wt:	710.11
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Cat. No.	Product name	Field of application
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DC72861	Diethyl Pyrocarbonate	Diethyl pyrocarbonate is a potent, non-specific inhibitor of RNase. It has been useful as an in vitro agent, relatively specific for binding to imidazole of histidine. It inhibits central chemosensitivity in rabbit and can modify Ser, Thr, His and Tyr residues.
DC72313	Dideoxy-amanitin	Dideoxy-amanitin (compound 2), an α-Amanitin derivative, is a potent and selective RNA polymerase II allosteric inhibitor with an IC50 value of 74.2 nM.
DC72169	RP-6685	RP-6685 is a potent, selective and orally active DNA polymerase theta (Polθ) inhibitor with an IC50 value of 5.8 nM (PicoGreen assay). RP-6685 shows antitumor efficacy in mouse tumor xenograft model.
DC71300	Branaplam hydrochloride	Branaplam (LMI070; NVS-SM1) hydrochloride is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC50 of 20 nM for SMN. Branaplam hydrochloride inhibits human-ether-a-go-go-related gene (hERG) with an IC50 of 6.3 μM. Branaplam hydrochloride elevates full-length SMN protein and extends survival in a severe spinal muscular atrophy (SMA) mouse model.
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