lavendustin B|cas 125697-91-8|DC Chemicals

Cas No.:	125697-91-8
Chemical Name:	Benzoic acid,5-[bis[(2-hydroxyphenyl)methyl]amino]-2-hydroxy-
Synonyms:	Benzoic acid,5-[bis[(2-hydroxyphenyl)methyl]amino]-2-hydroxy-;Lavendustin B;5-[bis[(2-hydroxyphenyl)methyl]amino]-2-hydroxybenzoic acid;N,N-BIS(2'-HYDROXYBENZYL)-3-AMINOSALICYLIC ACID;5-AMINO-(N,N'-BIS-2-HYDROXYBENZYL)SALICYLIC ACID;2-Hydroxy-5-[bis(2-hydroxybenzyl)amino]benzoic acid;5-[Bis[(2-hydroxyphenyl)Methyl]aMino]-2-hydroxy-benzoic Acid
SMILES:	OC1C=CC=CC=1CN(CC1C=CC=CC=1O)C1=CC(C(O)=O)=C(O)C=C1
Formula:	C₂₁NO₅H₁₉
M.Wt:	365.3793
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	Lavendustin B is an inhibitor of HIV-1 integrase interaction with LEDGF/p75 with an IC50 of 94.07 μM. Lavendustin B is an ATP-competitive GLUT1 inhibitor with a Ki of 15 µM. Lavendustin B is also a weak inhibitor of tyrosine kinases[1][2].
In Vitro:	In HL-60 cells, Lavendustin B (0-1000 µM) inhibits the uptake of methylglucose, deoxyglucose, and dehydroascorbic acid in human erythrocytes in a dose-dependent manner, with 50% inhibition observed at approximately 10-30 µM. Moreover, increasing concentrations of Lavendustin B inhibited, in a dose-dependent manner, the binding of cytochalasin B to human erythrocyte membranes[1].
References:	[1]. J C Vera, et al. Direct inhibition of the hexose transporter GLUT1 by tyrosine kinase inhibitors. Biochemistry. 2001 Jan 23;40(3):777-90. [2]. Fatima E Agharbaoui, et al. Computational and synthetic approaches for developing Lavendustin B derivatives as allosteric inhibitors of HIV-1 integrase. Eur J Med Chem. 2016 Nov 10;123:673-683.

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