MK-8262|CAS 1432054-03-9|DC Chemicals

Cas No.:	1432054-03-9
Chemical Name:	MK-8262
Synonyms:	Benzoic acid, 4-[5-[2-[(1R,5S,7aS)-1-[3,5-bis(trifluoromethyl)phenyl]tetrahydro-3-oxo-1H,3H-pyrrolo[1,2-c]oxazol-5-yl]-4-(trifluoromethyl)phenyl]-6-methoxy-3-pyridinyl]-3-methyl-;MK-8262
SMILES:	C(O)(=O)C1=CC=C(C2=CC(C3=CC=C(C(F)(F)F)C=C3[C@H]3N4[C@@]([H])(CC3)[C@@H](C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)OC4=O)=C(OC)N=C2)C(C)=C1
Formula:	C₃₅H₂₅F₉N₂O₅
M.Wt:	724.569041013718
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Cat. No.	Product name	Field of application
DC46394	MK-8262	MK-8262 is an orally active and potent cholesteryl ester transfer protein (CETP) inhibitor with an IC50 of 53 nM and a log D of 5.3. MK-8262, a bistrifluoromethyl analogue, has the potential for coronary heart disease (CHD) correlated high-density lipoprotein (HDL) and low-density lipoprotein (LDL) research.
DC7519	Torcetrapib	Torcetrapib is a CETP inhibitor with IC50 of 37 nM, elevates HDL-C and reduces nonHDL-C in plasma. Phase 3.
DC7125	Evacetrapib (LY2484595)	Evacetrapib (LY2484595) is a potent and selective inhibitor of CETP with IC50 of 5.5 nM, elevates HDL cholesterol without increases in aldosterone or blood pressure.
DC7804	Anacetrapib(MK0859)	Anacetrapib (MK0859) is a potent, selective, reversible rhCETP and mutant CETP(C13S) inhibitor with IC50 of 7.9 nM and 11.8 nM, increases HDL-C and decreases LDL-C, does not increase aldosterone or blood pressure. Phase 3.