MLT-827|CAS 2682102-03-8|DC Chemicals

Cas No.:	2682102-03-8
Chemical Name:	MLT-827
Formula:	C₂₂H₂₁ClN₆O₃
M.Wt:	452.9

Cat. No.	Product name	Field of application
DC46393	JNJ-67856633	JNJ-67856633 is an orally active, first-in-class, potent, selective and allosteric MALT1 protease inhibitor. JNJ-67856633 in some cases lead to tumor stasis.
DC76984	(S,R,S)-AHPC-Boc derivative 1	(S,R,S)-AHPC-Boc derivative 1 (Compound 80-9; VH032-Boc derivative 1) is a selective proteasomal degrader targeting MALT1, which recruits the E3 ubiquitin ligase CRBN to form a ternary complex with MALT1, leading to ubiquitination and subsequent proteasomal degradation of MALT1. (S,R,S)-AHPC-Boc derivative 1 inhibits the NF-κB signaling pathway by disrupting the CBM complex, demonstrating potential for inducing apoptosis in ABC-DLBCL cells. (S,R,S)-AHPC-Boc derivative 1 is promising for research of MALT1-dependent cancers, such as diffuse large B-cell lymphoma (DLBCL).
DC73799	MLT-943	MLT-943 is a potent and selective MALT1 protease inhibitor with IC50 of 40 nM in IL-2 reporter gene assay (Jurkat T cells), inhibits human PBMC IL-2 release with IC50 of 74 nM.
DC73798	MLT-827	MLT-827 is a potent and selective inhibitor of MALT1 paracaspase activity with IC50 of 5 nM.
DC72804	Z-VRPR-FMK	Z-VRPR-FMK is an irreversible MALT1 protein inhibitor. Z-VRPR-FMK inhibits the growth and invasion of diffuse large B-cell lymphoma by inhibiting MALT1-induced NF-κB activation and MMP expression.
DC72411	RGT-068A	RGT-068A is a potent, selective and oral bioavailable MALT1 inhibitor.
DC72232	NVS-MALT1	NVS-MALT1 is a MALT1 allosteric inhibitor.
DC70983	(R)-MLT-985	(R)-MLT-985 (compound 11) is a potent MALT1 protease inhibitor with an IC50 of 3 nM. (R)-MLT-985 has an IC50 of 20 nM for MALT1-dependent IL-2 production in Jurkat cells. (R)-MLT-985 suppresses growth and aberrant CARD11/BCL10/MALT1 complex signaling in ABC-DLBCL cells.