MTK458|CAS 2499962-58-0 |DC Chemicals

Cas No.:	2499962-58-0
Chemical Name:	Mitophagy activator 1
Synonyms:	Mitophagy activator 1;EX-A8247;N-[(1R)-1,2,3,4-Tetrahydro-1-naphthalenyl]-6-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine;2499962-58-0;(R)-N-(1,2,3,4-Tetrahydronaphthalen-1-yl)-6-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine;GLXC-27505;7H-Pyrrolo[2,3-d]pyrimidin-4-amine, N-[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]-6-(trifluoromethyl)-;GTPL13011;MTK-458;JOIONRWKOGDQOG-CYBMUJFWSA-N;CS-0651799;MTK458;LN62PXZ9FP;N-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]-6-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine;HY-152943;SCHEMBL22524225
SMILES:	FC(C1=CC2C(=NC=NC=2N[C@H]2C3C=CC=CC=3CCC2)N1)(F)F
Formula:	C₁₇H₁₅F₃N₄
M.Wt:	332.323013544083
Purity:	98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Cat. No.	Product name	Field of application
DC72873	MTK458	MTK458 (MTK-458) is a potent, selective and brain penetrant PINK1 activator, MTK-458 promotes the first step in mitophagy. MTK458 selectively activates PINK1 by stimulating dimerization and stabilization of the PINK1/TOM complex. MTK458 binds to PINK1 and stabilizes an active heterocomplex, thereby increasing mitophagy. MTK458 reduces the PINK1 substrate pS65-Ubiquitin (pUb) in primary neurons and in vivo. MTK458 drives clearance of pathologic α-synuclein in vitro and in vivo, decreases pS129 α-synuclein aggregates and normalized both brain and corresponding plasma pUb levels in both cellular and animal models of α-synuclein aggregation (PD-like pathology).