NLX-204|CAS 2170405-10-2|DC Chemicals

Cas No.:	2170405-10-2
Chemical Name:	NLX-204 HCl
Synonyms:	NLX204;NLX 204
SMILES:	C(C1=CC=C(F)C(Cl)=C1)(N1CCC(F)(CNCCOC2=NC=CC=C2)CC1)=O
Formula:	C₂₀H₂₃Cl₂F₂N₃O₂
M.Wt:	445.114
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Cat. No.	Product name	Field of application
DC70655	NLX-204	NLX-204 is a potent and selective ERK1/2 phosphorylation-preferring serotonin 5 HT1A receptor agonist with pKi = 10.19. NLX-204 displayed high selectivity in the SafetyScreen44 panel (including hERG channel), high solubility, metabolic stability, and Caco-2 penetration and did not block CYP3A4, CYP2D6 isoenzymes, or P-glycoprotein. Preliminary in vivo studies confirmed its promising pharmacokinetic profile. NLX-204 also robustly stimulated ERK1/2 phosphorylation in rat cortex and showed highly potent (MED = 0.16 mg/kg) and efficacious antidepressant-like activity, totally eliminating immobility in the rat Porsolt test.
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