Rebecsinib|CAS 2598242-04-5|DC Chemicals

Cas No.:	2598242-04-5
Chemical Name:	Rebecsinib (17S-FD-895)
Synonyms:	AT44216;REBECSINIB (17S-FD-895);REBECSINIB (17S-FD-895);REBECSINIB (17S-FD-895);REBECSINIB (17S-FD-895);REBECSINIB (17S-FD-895);2598242-04-5;2598242-04-5;2598242-04-5;2598242-04-5;2598242-04-5
SMILES:	O1[C@H]([C@H]([C@@H](/C=C/C=C(\C)/[C@@H]2[C@@H](C)C=C[C@@H]([C@@](C)(CC[C@H](CC(=O)O2)O)O)OC(C)=O)C)O)[C@@H]1[C@H](C)[C@H](CC)OC \|t:12\|
Formula:	C₃₁H₅₀O₉
M.Wt:	566.723310947418
Purity:	98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Cat. No.	Product name	Field of application
DC74241	Rebecsinib	Rebecsinib (17S-FD-895) is a selective small-molecule inhibitor of splicing-mediated ADAR1 activation, prevents leukemia stem cell generation.
DC70864	UHMCP1	UHMCP1 is a small molecule that prevents the SF3b155/U2AF65 interaction, binds to the hydrophobic pocket of the U2AF65 UHM domain (Kd=1-20 uM), impacts splicing and cell viability.
DC70497	HTT-D3	HTT-D3 is a potent, CNS-penetrant, orally bioavailable huntingtin (HTT) splicing modulator, affects HTT pre-mRNA splicing and reduces HTT expression with IC50 of 8 nM.Oral administration of HTT-D3 resulted in dose-dependent and approximately equivalent mHTT protein lowering in both brain and peripheral tissues in mouse models carrying human mHTT transgene, BACHD and Hu97/18.HTT-D3 (10 mg/kg) reduced mHTT mRNA and protein levels in BACHD brain in BACHD mice.