RS6212|CAS 2097925-52-3|DC Chemicals

Cas No.:	2097925-52-3
Chemical Name:	RS6212
SMILES:	O=C1C=C(CCC2)C2=NN1CC3CCN(C(C4=CC=CC=C45)=NS5(=O)=O)CC3
Formula:	C₂₀H₂₂N₄O₃S
M.Wt:	398.48
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Cat. No.	Product name	Field of application
DC48820	hDHODH-IN-8	hDHODH-IN-8 is a potent inhibitor of human dihydroorotate dehydrogenase (hDHODH) with an IC50 of 16 nM. hDHODH-IN-8 has potent antiproliferative activity and excellent aqueous solubility. hDHODH-IN-8 has the potential for the research of tumor disease, especially lymphoma.
DC28916	DHODH-IN-11	DHODH-IN-11 (Compound 14b) is a Leflunomide derivative and a weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03[1].
DC71970	RS6212	RS6212 is a specific LDH (lactate dehydrogenase) inhibitor with an IC50 value of 12.03 μM . RS6212 inhibits tumor growth and exhibits potent anticancer activity in multiple cancer cell lines.
DC70226	AXKO-0046	AXKO-0046 (AXKO0046) is the first highly selective, small molecule inhibitor of human lactate dehydrogenase B (LDHB), exhibits uncompetitive LDHB inhibition with EC50 of 42 nM.AXKO-0046 selectively inhibited LDHB activity in an uncompetitive manner with respect to NADH and pyruvate, no inhibitory activity against LDHA at 300 uM.AXKO-0046 did not bind in the catalytic site of the enzyme but significantly bound to LDHB in the novel allosteric site of the tetramer.AXKO-0046 is a promising chemical probe to elucidate the role of LDHB-associated pathways in cancer metabolism.
DC47963	LDHA-IN-5	LDHA-IN-5 is a novel, potent, dual GO/LDHA inhibitor for primary hyperoxaluria.