STAT3 inhibitor N4|CAS 2225879-93-4|DC Chemicals

Cas No.:	2225879-93-4
Chemical Name:	STAT3 inhibitor N4
Synonyms:	STAT3 inhibitor N4;(4bS,8aS)-6-Cyano-4b,7,8,8a,9,10-hexahydro-3-methoxy-4b,8,8-trimethyl-7-oxo-N-8-quinolinyl-2-phenanthrenecarboxamide
SMILES:	C[C@]12C=C(C#N)C(=O)C(C)(C)[C@@]1([H])CCC1=CC(C(=O)NC3=CC=CC4C=CC=NC3=4)=C(OC)C=C21
Formula:	C₂₉H₂₇N₃O₃
M.Wt:	465.542987108231
Purity:	98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Cat. No.	Product name	Field of application
DC73586	STAT3-SH2 domain inhibitor 1	STAT3-SH2 domain inhibitor 1 is a potent Src Homology 2 (SH2) Domain of STAT3 (STAT3-SH2 domain) inhibitor with a Kd value of 1.57 μM. STAT3-SH2 domain inhibitor 1 inhibits STAT3 signaling transduction and transcriptional activation. STAT3-SH2 domain inhibitor 1 induces apoptosis in gastric cancer cells. STAT3-SH2 domain inhibitor 1 can be used in research of cancer.
DC70809	STAT3 inhibitor N4	STAT3 inhibitor N4 is a small molecule capable of inhibiting the STAT3 SH2 domain with IC50 of 0.57 uM, SPR KD of 1.04 uM, inhibits STAT3 dimerization and transcription in vitro and suppresses pancreatic cancer in vivo.N4 suppresses STAT3 activation in pancreatic cancer cells, suppresses pancreatic cancer cell growth, migration, and induces apoptosis.N4 (20 mg/kg, i.p.) suppresses pancreatic cancer growth, exhibits potent anti-metastatic activity in a pancreatic cancer liver metastasis mouse model, and prolongs survival of tumor-bearing mice.
DC45278	Colivelin	Colivelin is a brain penetrant neuroprotective peptide and a potent activator of STAT3, suppresses neuronal death by activating STAT3 in vitro. Colivelin exhibits long-term beneficial effects against neurotoxicity, Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease. Colivelin has the potential for the treatment of alzheimer's disease and ischemic brain injury
DC8726	FLLL31	FLLK31 is a potent and selective inhibitor of the STAT3 signaling pathway.