TP0597850|CAS 2642181-22-2|DC Chemicals

Cas No.:	2642181-22-2
Chemical Name:	TP0597850
SMILES:	NC(CCCCNC([C@H](CCC(O)=O)N(C)C([C@H](CC(C)C)NC([C@H]1N(C[C@H](C1)N)C(CC[C@H](C(O)=O)NS(=O)(C2=CC=C(C=C2)NC(C3=CC=C(C=C3)C(N)=O)=O)=O)=O)=O)=O)=O)=O
Formula:	C₄₁H₅₇N₉O₁₃S
M.Wt:	916.01
Purity:	98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Cat. No.	Product name	Field of application
DC72785	TP0597850	TP0597850 is a selective inhibitor of MMP2 (IC50=0.22 nM). TP0597850 has a long MMP2 dissociation half-life (t1/2=265 min).
DC8131	TAPI-2 (TNF Protease Inhibitor 2)	TAPI-2 inhibits ADAM8, 10, 12, and TACE with Ki values of 10, 3, 100, and 0.12 µM, respectively.
DC10713	S-methyl-KE-298	S-methyl-KE-298 is an active metabolite of KE-298. KE-298 inhibits matrix metalloproteinase (MMP-1) production from rheumatoid arthritis (RA) synovial cells.
DC7670	SB-3CT	SB-3CT is an effective and selective gelatinase inhibitor with Ki of 13.9 nM and 600 nM for MMP-2 and MMP-9, respectively.
DC7215	NSC 405020	NSC 405020 is a noncatalytic inhibitor of MT1-MMP, directly interacts with PEX domain of MT1-MMP, affects PEX homodimerization but not catalytic activity of MT1-MMP.
DC11404	JNJ0966	JNJ0966 is a highly selective compound that inhibited activation of MMP-9 zymogen and subsequent generation of catalytically active enzyme.
DC7135	GM6001 (galardin, ilomastat)	GM6001 (galardin, ilomastat) is a broad spectrum MMPs inhibitor for MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-12, MMP-14, and MMP-26 with Ki of 0.4-27 nM.
DC10883	GI254023X	GI254023X is a potent MMP9 and ADAM10 inhibitor with IC50s of 2.5 and 5.3 nM, respectively.
DC11447	Astragaloside IV	Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells.