ZN-c3|CAS 2376146-48-2|DC Chemicals

Cas No.:	2376146-48-2
Chemical Name:	ZN-c3
Synonyms:	ZN-C3;ZN-C3 [WHO-DD];9J13XU96Z1;3H-Pyrazolo(3,4-d)pyrimidin-3-one, 1-((7R)-7-ethyl-6,7-dihydro-7-hydroxy-5H-cyclopenta(b)pyridin-2-yl)-1,2-dihydro-6-((4-(4-methyl-1-piperazinyl)phenyl)amino)-2-(2-propen-1-yl)-;ZN-c3
SMILES:	O[C@@]1(CC)C2C(=CC=C(N3C4C(=CN=C(NC5C=CC(=CC=5)N5CCN(C)CC5)N=4)C(N3CC=C)=O)N=2)CC1
Formula:	C₂₉H₃₄N₈O₂
M.Wt:	526.632665157318
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	ZN-c3 is an orally active, highly potent and selective Wee1 inhibitor (IC50=3.9 nM). ZN-c3 can be used for the research of cancer.
Target:	IC50: 3.9 nM (Wee1)[1]
In Vivo:	ZN-c3 (80 mg/kg; p.o.; 28 days) can effectively shrank tumors at 80 mg/kg as a single agent[1]. ZN-c3 shows excellent exposures and bioavailability in the dog PK study[1].
In Vitro:	ZN-c3 IC50 is 103 nM in H23c cells[1].
References:	[1]. Huang PQ, et al. Discovery of ZN-c3, a Highly Potent and Selective Wee1 Inhibitor Undergoing Evaluation in Clinical Trials for the Treatment of Cancer [published online ahead of print, 2021 Aug 23]. J Med Chem. 2021;10.1021/acs.jmedchem.1c01121.

Cat. No.	Product name	Field of application
DC70350	Debio 0123	Debio 0123 (Debio0123) is a potent, orally available, and highly selective Wee1 kinase inhibitor with IC50 of 0.8 nM, Ki of 0.1 nM.Debio 0123 is highly selective to Wee1 on 465 selected kinases in a cellfree system, does not inhibit Plk1 and Plk2, as also reported in recent publications for AZD1775.Debio 0123 exhibits in vitro growth inhibition activity in a broad number of human cancer cell lines (IC50= 0.109 to 7.08 uM).Debio 0123 prevent CDC2 / Cdk1 phosphorylation, induces γH2AX and enhances phosphorylation of histone H3.Debio 0123 induces apoptosis through mitotic catastrophe following cell cycle progression despite accumulation of unrepaired DNA damage both in vitro and in vivo.
DC46399	ZN-c3	ZN-c3 is an orally active, highly potent and selective Wee1 inhibitor (IC50=3.9 nM). ZN-c3 can be used for the research of cancer.