PTP1B-IN-13 is a selective PTP1B inhibitor targeting the allosteric site with an IC50 value of 1.59 μM.

PDE4-IN-3 is a novel and orally active PDE4 inhibitor with potent inhibitory affinity (IC50 = 4.2 nM).

N-Desmethyl Sildenafil (Desmethylsildenafil) is a major metabolite of Sildenafil. Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor.

PCSK9-IN-2 is a novel small molecule inhibitor of PCSK9-LDLR protein–protein interaction (PPI) with an IC50 value of 7.57 μM.

Chikusetsusaponin Ib has anti-Alzheimer's disease activity and is a potent AChE inhibitor.

Cyclopenin ((±)-Isocyclopenine) is a racemate.

Cyclanoline (chloride) shows cholinesterase inhibitory activity.

Isonaringin shows anti-Alzheimer’s activity by inhibiting AChE.

GCPII-IN-1 is a glutamate carboxypeptidase II (GCPII, or PSMA) inhibitor scaffold with a Ki of 44.3 nM.

Cathepsin L-IN-2 (Z-Phe-Phe-FMK) is a potent and irreversible cathepsin L and cathepsin B inhibitor.

Indoluidin E selectively inhibits DHODH and suppresses cancer cell growth.

DHODH-IN-18 is a human DHODH inhibitor (IC50 = 0.2 nM).

Ascochlorin A is a novel and potent hDHODH inhibitor (KD = 3.29 μM) for treatment of triple-negative breast cancer.

Ganoderlactone D shows inhibitory effects of yeast α-Glucosidase with IC50 values of 41.7 μM.

IDO-IN-14 is an IDO inhibitor with an IC50 value of 0.6928 nM.

IDO-IN-15 is an IDO1 inhibitor (IC50 < 0.51 nM).

D-Cl-amidine hydrochloride is a potent and highly selective PAD1 inhibitor. D-Cl-amidine is well-torelated with no significant toxicity.

(E)-Dehydrodiconiferyl alcohol behaves as good hCA IX and hCA XII dual inhibitors. And (E)-Dehydrodiconiferyl alcohol suppresses the NF-κB nuclear translocation in connective tissue of healing area.

ABP 25 is an activity-based probe for cathepsin K imaging with excellent potency and selectivity.

4-Hydroxytryptamine creatinine sulfate, a tryptamine derivative, is a neurotransmitter agonist.

ADAM8-IN-1 is a potent ADAM8 inhibitor with an IC50 value of 73 nM.

(S)-Salsolidine is a weak monoamine oxidase (MAO) inhibitor (Ki=63 μM). The R enantiomer of Salsolidine is more potent than the S form (Ki=26 μM).

(+)-Cinchonaminone shows monoamine oxidase (MAO) inhibitory activity.

28-O-β-D-Glucopyranosyl pomolic acid is a urokinase plasminogen activator inhibitor with IC50 at 37.82 μM.

Fitusiran (ALN-AT3SC), an small interfering RNA, specifically targets antithrombin (AT) messenger RNA to lower production of AT in the liver. Fitusiran increases thrombin generation and has the potential for the research of the hemophilia.

SLN124 is a GalNac-siRNA targeting transmembrane serine protease 6 (Tmprss6). SLN124 is composed of a trimeric GalNAc ligand conjugated to TMPRSS6‐siRNA. SLN124 has the potential for an siRNA to restore hepcidin expression and normalise iron homeostasis in β‐thalassaemia.

Zanapezil (TAK-147) free base is a potent, reversible and selective acetylcholine esterase (AChE) inhibitor. Zanapezil free base shows a potent and reversible inhibition of AChE activity in homogenates of the rat cerebral cortex (IC50=51.2 nM). Zanapezil free base shows a moderate inhibition of muscarinic M1 and M2 receptor binding with Ki values of 234 and 340 nM, respectively. Zanapezil free base can be used for the research of early stages of Alzheimer's disease (AD).

Kynuramine, an endogenously occurring amine, is a fluorescent substrate and probe of plasma amine oxidase.

Ro 20-1724 (Ro 20-174) is a potent inhibitor of cAMP-specific phosphodiesterase (PDE4/PDE IV) with a Ki of 1930 nM. Neuroprotective effect.

Phosphoribosyl pyrophosphate (PRPP) pentasodium is an important metabolite required in the biosynthesis of purine and pyrimidine nucleotides, the amino acids histidine and tryptophan, and the cofactors NAD and NADP.