Metixene hydrochloride hydrate is an anticholinergic antiparkinsonian agent, potently inhibits binding of quinuclidinyl benzilate (QNB) to the muscarinic receptor in rat brain cortical tissue, with an IC50 of 55 nM and a Kd of 15 nM.

Methylproamine is a DNA-binding radioprotector which, on the basis of published pulse radiolysis studies, acts by repair of transient radiation-induced oxidative species on DNA.

Methyliodobikinin is a potent bikinin-like inhibitor targeting GSK3/Shaggy-like kinase, shows improved cell permeability, highly potent in vivo although it had lower activity in vitro.

Methyl Gerfelin (M-GFN) is an osteoclastogenesis inhibitor (IC50=2.8 uM) through the competitive inhibition of glyoxalase I (GLO1) with Ki of 0.23 uM.

Methoxy-PEPy is a potent, selective mGlu5 receptor antagonist with IC50 of 1 nM.

MethADP is a specific CD73 inhibitor.

Metesind glucuronate (AG 331.

Metaxalone(AHR438;NSC170959) is a muscle relaxant used to relax muscles.

Metadoxine blocks adipocyte differentiation in association with inhibition of the protein kinase A-cAMP response element binding protein (PKA-CREB) pathway.

Meropenem

Mequitazine is a potent, nonsedative and long-acting histamine H1 antagonist.

MELK inhibitor 17 is a potent, selective MELK inhibitor with Ki/IC50 of 0.39/3 nM, >100-fold selectivity over CHK1, CAMKK2, NUAK1 and ERK2.

Melflufen (Melphalan flufenamide, J1) is a novel dipeptide and alkylating prodrug of melphalan, inhibits angiogenesis in vitro and in vivo.

Meleagrin is an antibiotic derived from a deep ocean, penicillin-producingP. chrysogenum.

Melanocyte-stimulating hormone release-inhibiting factor (MSH-R-IF) is a hypothalamic tripeptide that binds to rat striatum (Kd = 4.69 nM) and has diverse biological activities.

Meclizine is a histamine H1 receptor antagonist used to treat nausea and motion sickness.

Mebendazole is a synthetic benzimidazole derivate and anthelmintic agent. Mebendazole interferes with the reproduction and survival of helminths by inhibiting the formation of their cytoplasmic microtubules, thereby selectively and irreversibly blocking g

Meayamycin is an analogue of FR901464 that binds to the splicing factor 3b (SF3b) complex and inhibits pre-mRNA splicing, shows picomolar antiproliferative activity against various cancer cell lines and multidrug-resistant cells..

MDA 19 is a selective human CB2 receptor agonist with Ki of 43.3 nM.

MCT1-IN-4a is a potent, selective monocarboxylate transporter 1 (MCT1) inhibitor with IC50 of 90 nM.

MCOPPB 3Hcl is a nociceptin receptor agonist with pKi of 10.07; weaker activity at other opioid receptors.

Mcl-1-Puma inhibitor 8 is a small-molecule dual-acting compound that targets the apoptotic Mcl-1-PUMA interface with Ki of 0.3 uM (Mcl-1, FPA), reduces multiple cancer cells and inhibits PUMA-mediated apoptosis.

Mcl1-IN-2 is an Mcl-1 inhibitor without a reported IC50 value..

MCL0129 is a selective, potent melanocortin-4 receptor (MC4R) antagonist with Ki of 7.9 nM, without affinity for MC1 and MC3.

Mca-DEVDAPK(Dnp)-OH is a substrate for caspase-3.

MC2884 is a novel hybrid, dual HAT/EZH2 inhibitor with IC50 of 3.27, 8.35 and 4.56 uM for CBP, KAT5 and p300, respectively.

MC-1575 is a potent and selective class IIa HDAC inhibitor with IC50 of 440 nM for maize HD1-A, displays >70-fold selectivity over HD1-B.

MBQ-167 is a dual Rac/Cdc42 inhibitor, with IC50s of 103 nM for Rac 1/2/3 and 78 nM for Cdc42 in MDA-MB-231 cells, respectively.

MB710 is a small-molecule p53 mutant Y220C stabilizer, binds tightly to the Y220C pocket and stabilizes p53-Y220C in vitro..

MARPIN is a novel ATR-Chk1 pathway inhibitor that inhibits hydroxyurea (HU)-induced phosphorylation of Ser345 on Chk1 with IC50 of 7.7 uM.