Cefclidin (Cefclidine) belongs to the cephalomycin-type compound.

Cefbuperazone belongs to the cephalomycin-type compound.

C12-rrw-NH2 (Compound Lip7) is an antibacterial agent against gram-positive bacteria, especially against Methicillin. Sildenafil is a potent phosphodiesterase type 5 (PDE

BPH-608 is a bacterial undecenyl diphosphate synthase (UPPS) inhibitor (IC50=590 nM) with antibacterial activity.

BAS-118 is a benzamide derivative with antibacterial activity. The MIC50, MIC90 and MIC ranges of BAS-118 for 100 randomly selected isolates of Helicobacter pylori are ≤0.003, 0.013 and ≤0.003-0.025 mg/L, respectively. BAS-118 is promising for research of anti-H. pylori agent.

BAR-072 is a small-molecule inhibitor targeting TraE, with a KD of 2.7 µM. It significantly inhibits the transfer of the antibiotic resistance-associated plasmid pKM101. BAR-072 shows promise as a candidate compound for blocking the spread of bacterial resistance genes and holds potential for research in infectious disease and antimicrobial resistance control.

Bactobolin B (Alanylbactobolin) is a chlorine-containing antibiotic with antitumor activities.

Bacimethrin (NSC 66577) is an antibacterial agent and is thiamin biosynthesis antagonist.Bacimethrin inhibits bacterial and yeast growth.

Armentomycin (L-Armentomycin) is a nonprotein amino acid with antibiotic properties. Armentomycin mainly acts against Gram-negative bacteria.

Arizonin B1, a microbial metabolite, is an antibiotic with anti-Gram-positive bacterial activities.

Apoptosis inducer 33 (Compound H2) is a hydrazone derivative. Apoptosis inducer 33 has antioxidant and antibacterial activity that inhibits the growth of Staphylococcus aureus, Escherichia coli and Candida albicans. Apoptosis inducer 33 inhibits tumor cells proliferation and induces apoptosis, which can be used in the study of cancer.

apo-Enterobactin is a derivative of Enterobactin.

Antibacterial synergist 3 is a dual-acting inhibitor of biofilm (IC50 of PAO1: 0.40 μM and IC50 of PA14: 1.45 μM). Antibacterial synergist 3 reduces virulence production by inhibiting the quorum sensing (QS) system and induces iron deficiency in P. aeruginosa PAO1. Antibacterial synergist 3 enhances the efficacy of Tobramycin and Ciprofloxacin in a mouse wound infection model. Antibacterial synergist 3 can be used for the research of P. aeruginosa infections.

Angolamycin is a basic macrolide antibiotic active against Gram-positive bacteria.

Amidinomycin is mainly resistant to Gram-positive bacteria (weak).

Albonoursin, a microbial secondary metabolite, is an antibacterial peptide. Albonoursin displays antibacterial and antitumor activities.

Alahopcin is a dipeptide antibiotic with a broad antibacterial spectrum.

AK-968-11563024 is an inhibitor of marine V. vulnificus NAT [ (VIBVN)NAT] with an IC50 of 18.86 µM. NATs (Arylamine N-acetyltransferases) in marine V. vulnificus plays a role in drug metabolism, contributing to the development of drug resistance. Therefore, AK-968-11563024 can be utilized in research related to drug resistance.

9-tert-Butyldoxycycline exhibits immunomodulatory activity, alters the polarization states polymorphonuclear neutrophils, and ameliorates the inflammatory response in ischemia-reperfusion injury model. 9-tert-Butyldoxycycline is the ligand for ‘Tet-On’ switch system.

8-Nonynoic acid (non-8-ynoic acid) is a fatty acid that belongs to the group of octynoic acids. It exhibits antibacterial activity against gram-positive bacteria by binding to bacterial fatty acids. 8-Nonynoicacid also inhibits growth of gram-negative bacteria by inhibiting the synthesis of fatty acids. It is also capable of inhibiting growth of both aerobic and anaerobic bacteria in biochemical assays.

8-Hydroxyerythromycin is a semi-synthetic antibiotic with an antibacterial activity.

2,2',4'-Trichloroacetophenone (Compound 3) is an α-haloacetophenone analogue. 2,2',4'-Trichloroacetophenone exhibits good antibacterial activities against Xanthomonas oryzae pv. oryzae (Xoo) and Xanthomonas axonopodis pv. citri (Xac) with EC50 values of 0.54 and 2.02 mg/L, respectively. 2,2',4'-Trichloroacetophenone can be used for antibacteria study.

1-Aminoacridine (1-Acridinamine) is a bright fluorescent dye. 1-Aminoacridine acts as an anti-infective agent and mutagen due to its ability to interact with DNA.

11-Hydroxynovobiocin has anti-Gram-negative bacteria effect.

10-Deoxymethymycin (Antibiotic YC 17) displays antibiotic activity against Gram positive bacteria.

(R)-DS86760016 is the R-enantiomer of DS86760016 and a linker. Mc-Pro-PAB-MMAE can be used for synthesis of ADCs.

(E/Z)-MC4 is an enantiomer of the antibacterial agent MC4, which has antibacterial activity against a group of Staphylococcus aureus strains including MRSA, and has no significant toxicity to mammalian cells.

(-)-Luteoskyrin has a wide range of antibacterial activity, such as against malaria (with an IC50 of 0.51 μg/mL), tuberculosis (MIC of 6.25 μg/mL), and it also shows antibacterial effects (with MIC for Gram-positive bacteria ranging from 0.39 to 1.56 μg/mL, and for Gram-negative bacteria from 3.13 to 12.50 μg/mL), as well as antifungal activity (with MIC against plant pathogens ranging from 3.13 to 50μg/mL). (-)-Luteoskyrin exhibits cytotoxicity against NCI-H187 cells, with an IC50 range of 0.16–17.99 μg/mL.

A potent, selective, orally active orexin-2 receptor (OX2R) antagonist with pKi of 8.0 and 8.1 for human and rat OX2R, respectively.

IODVA1 is a small molecule with cellular inhibitory activity against several transformed cell lines including Ras-driven cells, targets Rac activation and signaling instead of Ras; IODVA1 inhibits ST8814 cell proliferation with GI50 of 1 uM, similar results were observed with MCF7, MDA-MB-231, and T47D cells with estimated GI50s <1 uM. IODVA1 significantly decreases number of colonies of the breast cancer cells in soft agar at 1 and 3 uM. IODVA1 probably does not bind Ras and that its mechanism of action is likely Ras-independent, inhibits lamellipodia and circular dorsal ruffle (CDR) formation in MDA-MB-231 cells and decreases Rac activation. IODVA1 inhibits Rac activation and downstream signaling leading to inhibition of lamellipodia and CDR formation; IODVA1 inhibits cell-substratum and cell-cell interactions, does not target kinases, and reduces tumor burden of solid tumors in vivo.