t-Boc-aminooxy-PEG1-propargyl is a PEG derivative containing a propargyl group and t-Boc-aminooxy group. The propargyl group can be reacted with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. PEG Linkers can be useful in the development of antibody drug conjugates.

Propargyl-PEG2-methylamine is a PEG derivative containing a propargyl group and methylamine group. The propargyl group can be reacted with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The methylamine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. PEG Linkers are useful in the development of antibody drug conjugates.

N-Me-N-bis(PEG2-propargyl) is a crosslinker containing two propargyl groups at each terminal end. The propargyl groups can be reacted with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield stable triazole linkages. PEG Linkers can be useful in the development of antibody drug conjugates.

Propargyl-PEG3-bromide is a PEG derivative containing a propargyl group and a bromide group. The propargyl group can be reacted with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. PEG Linkers are useful in the development of antibody drug conjugates.

Propargyl-PEG4-(CH2)3-acid is a PEG derivative containing a propargyl group with a terminal carboxylic acid. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The propargyl group can be reacted with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage.

Propargyl-PEG6-acid is a PEG derivative containing a propargyl group with a terminal carboxylic acid. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The propargyl group can be reacted with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage.

Actarit is a drug that has been shown to suppress disease activity of rheumatoid arthritis (RA). Actarit reduces spontaneous tumor necrosis factor-alpha and interleukin 1beta secretion by primary synovial cells of patients with RA. Actarit likely acts on RA synovial cells to reduce cell-cell interactions with autologous synovium infiltrating lymphocytes and to inhibit proinflammatory cytokine and MMP production, leading to amelioration of symptoms of RA.

Tartrazine is an anionic, hydrophilic azo dye with an orange-yellow color used in fabrics, foods and cosmetics, and as a biological stain. It triggers amorphous aggregation in cationic myoglobin.

Angustmycin A is a nucleoside-analog inhibitor of GMPS (guanosine monophosphate synthase) produced by Streptomyces hygroscopius that efficiently suppresses melanoma cell invasion in vitro and tumorigenicity in immunocompromised mice. Angustmycin A may be used as an anti-melanoma agent when considering GMPS as a driver of melanoma.

DTCBPy is an efficient thermally activated delayed fluorescence (TADF) molecule.

L-4FPG is an inhibitor of the neutral amino acid transporters ASCT1 and ASCT2. L-4FPG shows good brain penetration and potently reduces amphetamine-induced hyperlocomotion.

Glasdegib Maleate is a potent and orally bioavailable inhibitor of smoothened.

Nagilactone B is a unique selective LXR regulator which suppresses atherosclerosis in apoE-deficient mice via promotion of cholesterol efflux in macrophages.

SRI-29574 is an allosteric dopamine transporter ligand.

DBC is a ubiquitous environmental pollutant, inducing significant DNA strand break levels and micronuclei in HepG2 cells.

FHZ is a highly selective, cell-permeable, non-cytotoxic probe for dual channel detection of (OH radical) and HOCl in live cells and zebrafish embryos.

ADP Sodium is an adenine nucleotide, converting into ATP by ATP synthases, affecting platelet activation through its interaction with P2Y1, P2Y12 and P2X1.

NVS-CECR2-1 is a potent and selective CECR2 inhibitor.

Nor-SCH-12679 Maleate is a D1-dopamine receptor antagonist.

AM-404 is a selective inhibitor of the carrier-mediated transport of anandamide without affecting anandamide hydrolysis.

Amiloride HCl anhydrous is a Na+ channel blocker. It acts by blocking TRPP3, acid sensing- (ASIC) and mechanogated membrane-ion channels, as well as the Na+/H+ exchanger.

C527 is a inhibitor of USP1 target ID1 degradation in leukemic cells.

ACPT-1 is an agonist of group III mGlu receptors.

NAD-299 HCl is a high affinity 5-HT1A receptor antagonist.

VPC-14228 is a specific inhibitor of AR-DBD. It acts by inhibiting both Y594A and Q592A mutants, blocking the interaction of the AR with androgen response elements in the nucleus..

Akt Inhibitor X is a cell permeable, reversible, and selective Akt phosphorylation inhibitor.

Methiothepin Maleate is an inhibitor of HCV infection and cell-to-cell transmission that acts by targeting the HCV E2 glycoprotein.

Fenoterol is β2-Adrenergic receptor (β2-AR) agonist. Fenoterol is chemically closely related to metaproterenol (orciprenaline). It has a higher bronchodilating potency than metaproterenol, albuterol (salbutamol in Europe) or terbutaline. The beta 2 selectivity of fenoterol at normal oral and inhaled doses is the same as for albuterol and terbutaline. Its pharmacodynamic effects are similar to those of other selective beta 2-adrenoceptor agonists.

RA-2 is a pan-negative-gating modulator of KCa2/3 channels. It acts by inhibiting EDH-type relaxation in coronary arteries.

(+)-Pinanediol is an effective inducer of melanogenesis. It acts by inducing higher levels of pigmentation and synthesis of nitric oxide (NO) in S91 cells.