Methyltetrazine-PEG4-azide is a PEG derivative containing an azide group and a methyltetrazine moiety. The azide group enables Click Chemistry in organic solvents or aqueous media. The hydrophilic PEG spacer increases water-solubility and provides a long and flexible connection. This reagent can be used to efficiently incorporate tetrazine groups onto alkyne-modified peptides or oligonucleotides.

Methyltetrazine-PEG5-alkyne is a PEG derivative containing an alkyne group and a hydrophilic PEG spacer. This reagent enables simple and efficient incorporation of a tetrazine moiety onto antibodies, cysteine-containing peptides, and other thiol-containing molecules. The alkynes can be reacted with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield stable triazole linkages.

Methyltetrazine-PEG5-NHS ester is a PEG derivative containing a tetrazine group and an NHS ester. THe hydrophilic PEG spacer arm improves water solubility and is transferrable to the labeled molecule, reducing aggregation of labeled proteins stored in solution. The NHS ester can react specifically and efficiently with primary amines such as the side chain of lysine residues or aminosilane-coated surfaces at neutral or slight basic conditions to form a covalent bond.

Methyltetrazine-PEG4-amine HCl salt is a PEG derivative containing a free amine and a methyltetrazine group. It is one of the most stable tetrazines commercially available. Methyl group improves the stability and hydrophilic PEG spacer increases water-solubility. This reagent is supplied as HCl salt for improved stability and easy handling.

Methyltetrazine-propylamine HCl salt is a PEG derivative containing methyltetrazine and is one of the most stable tetrazines commercially available. Methyl group can improve the stability of methyltetrazine-Propylamine. This reagent is supplied as HCl salt for improved stability and easy handling.

TCO-PEG4-acid is a non-activated PEG derivative containing a TCO moiety and a terminal carboxylic acid. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media and this reagent can be used to derivatize amine-containing molecules through a stable amide bond in the presence of activators (e.g. EDC, or HATU) .

N-Tos-N-(t-butoxycarbonyl)-aminoxy-PEG4-Tos is a PEG Linker.

S-acetyl-PEG6-Tos is a PEG Linker.

Tos-PEG3-CH2CO2H is a PEG derivative containing a tosyl group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond.

t-Butoxycarbonyl-PEG5-sulfonic acid is a PEG Linker.

t-Butoxycarbonyl-PEG4-sulfonic acid is a PEG Linker.

t-Butoxycarbonyl-PEG2-sulfonic acid is a PEG Linker

Bis-PEG4-sulfonic acid is a PEG Linker

PEG4-bis(phosphonic acid diethyl ester) is a PEG Linker.

m-PEG5-phosphonic acid ethyl ester is a PEG Linker.

m-PEG5-phosphonic acid is a PEG Linker.

2-(t-Butoxycarbonylamido)-1,3-bis(PFP-oxycarbonylethoxy)propane is a PEG Linker.

3,4-Dibromo-Mal-PEG2-Boc-Amine is a PEG Linker.

3,4-Dibromo-Mal-PEG2-Amine TFA salt is a PEG Linker.

Mal-PEG1-Bromide contains a maleimide group and bromide group. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions.

Mal-amido-PEG4-TFP ester is a PEG Linker.

Mal-PEG5-PFP is a PEG Linker.

Mal-PEG3-PFP is a PEG Linker.

Mal-PEG2-PFP is a PEG Linker

Mal-PEG1-PFP is a PEG Linker.

Mal-PEG5-NHS ester is a PEG derivative containing a maleimide group and an NHS ester group. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.

Mal-PEG8-acid is a PEG derivative containing a maleimide group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond.

Trityl-PEG8-azide is a PEG derivative containing an azide group and a trityl protected ester. Trityl group can be removed under acid conditions or hydrogenolysis. The azide group enables Click Chemistry. The hydrophilic PEG spacer increases solubility in aqueous media.

Azido-PEG4-acrylate is a crosslinker containing an azide group and an acrylate group. The azide group enables Click Chemistry and the acrylate group enables Michael addition. The hydrophilic PEG spacer increases solubility in aqueous media.

Azide-PEG3-Tos is a PEG derivative containing an azide group and a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The tosyl group is a good leaving group for nucleophilic substitution reactions.