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Novel inhibitors

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Cat. No. Product Name Field of Application Chemical Structure
DC34401 NTE-122
NTE-122 is a potent, selective and competitive inhibitor of Acyl-CoA:cholesterol acyltransferase (ACAT).
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DC34368 DHQ
DHQ is an inducer of ATPase activity of Herpes Simplex Virus thymidine kinase.
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DC34323 WST-1
WST-1 is a chromogenic indicator for NADH.
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DC34318 NSC756093
NSC756093 is the first inhibitor of the GBP1:PIM1 interaction.
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DC34317 Arylquin-1
Arylquin-1 is a secretagogue of prostate apoptosis response-4 (Par-4). It acts by displacing Par-4 from vimentin for secretion and triggering the efficient paracrine apoptosis of diverse cancer cells.
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DC34301 SAFit2
SAFit2 is a selective inhibitor of the ?FK506-binding protein 51 (FKBP51).
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DC34291 alphaSYN-IN-NAB2
alphaSYN-IN-NAB2 is an inhibitor of α-synuclein mutations. It acts by reversing the α-synuclein-induced pathological phenotype in Parkinson's disease cortical neurons and promoting E3 ubiquitin ligase Rsp5/Nedd4-dependent endosomal transport..
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DC34241 TASIN-1 Hydrochloride
TASIN-1 Hydrochloride is a truncated APC selective inhibitor. It acts by selectively killing colorectal cancer cells that express truncated APC by reducing cellular cholesterol levels and inducing apoptotic cell death through the ER stress/ROS/JNK signaling in colon cancer cells.
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DC34236 p-BrBzGSH(Cp)2
p-BrBzGSH(Cp)2 is an inhibitor of glyoxylase 1 (GLO1). It acts by increasing DNA-AGEs, stimulating RAGE expression, and inhibiting brain tumor growth in orthotopic mouse models.
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DC34225 Aminoluciferin
Aminoluciferin is a luciferin derivative as functional bioluminogenic substrate.
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DC34221 PF2562
PF2562 is a non-catechol dopamine 1 receptor agonist. Dopamine D1 receptors are implicated in numerous neuropharmacological and neurobiological functions. For example, D1 receptors are involved in different types of memory function and synaptic plasticity.
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DC34202 Phosphoramidon disodium
Phosphoramidon disodium is a neutral endopeptidase (neprilysin) inhibitor. It blocks degradation of amyloid β peptides and endothelin converting enzyme (ECE).
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DC34198 (-)-Pironetin
Pironetin is a natural α-tubulin-binding agent with potent antiproliferative activity. It acts by inhibiting cell division by forming a covalent adduct with α-tubulin.
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DC34185 5-TAMRA SE
5-TAMRA SE is a fluorescent amino-group-reactive probe for DNA and RNA.
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DC34134 DL-Phenylephrine hydrochloride
DL-Phenylephrine HCl is a selective alpha1-adrenergic receptor agonist.
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DC34131 Trans-Zeatin
Trans-Zeatin is a plant hormone that promotes growth of lateral buds, stimulates seed germination and seedling growth, and induces cell division.
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DC34121 Hematin
Hematin is an iron-containing porphyrin used for testing in vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens.
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DC34119 DBT
DBT is a far-red/near-infrared fluorescence light-up probe for specific in vitro and in vivo imaging of tumour-related proteins.
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DC34067 PF-6422899
PF-6422899 is an irreversible inhibitor of EGFR kinase activity. PF-6422899 binds covalently to active-site cysteine residues in the ATP binding pocket of EGFR.
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DC33996 Long trebler phosphoramidite
Long trebler phosphoramidite is a branching reagent for oligonucleotide synthesis allowing to synthesize branched DNA structures using a standard DNA synthesizer.Trebler amidite can be used to attach several modifier amidites to the 5'-end of an oligonucleotide - for example, three biotin residues can be attached at once.
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DC33952 Cyanine7
Near infrared dye with free amine group for the conjugation with activated esters and other reactive molecules. Cyanine7 is a near infrared dye, an analog of Cy7? which is especially suitable for live organism imaging, and demanding low-background applications.
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DC33934 Cyanine7 carboxylic acid
Free unactivated Cyanine7 dye carboxylic acid. Near-infrared fluorescent dye.
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DC33928 BDP TR carboxylic acid
BDP TR is a bright and photostable fluorophore for ROX/Texas red channel. It is moderately hydrophobic, has relatively long lifetime of the excited state, and significant two photon cross section. This carboxylic acid derivative can be used for the labeling of alcohols by Steglich esterification, or in non-conjugated form (non-activated carboxy group can be considered inert for applications that do not require conjugation).
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DC33903 Sulfo-Cyanine3 maleimide
Sulfo-Cyanine3 maleimide is a water soluble, thiol reactive dye for the labeling with hydrophilic sulfo-Cyanine3 fluorophore. This is an analog of Cy3? maleimide. This product is recommended for the labeling of antibodies and other labile proteins in mild, purely aqueous conditions. The dye is water soluble and does not require use of organic co-solvent.
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DC33898 Cyanine5.5 maleimide
Cyanine5.5 maleimide is a thiol reactive dye which is capable of selective labeling of sulfhydryl groups in proteins, an analog of Cy5.5? maleimide. Near infrared emission of Cyanine5.5 makes this dye suitable for bioimaging applications. Cyanine5.5 can replace Cy5.5?, Alexa Fluor 680, and DyLight 680.
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DC33885 Sulfo-Cyanine 5 alkyne
Water soluble reagent with alkyne group for Click Chemistry. Sulfo-Cyanine5 is a sulfonated dye, which possesses high hydrophilicity and aqueous solubility, exceptionally high extinction coefficient, good quantum yield, and compatibility with many instruments. This reagent is recommended for the conjugation with proteins, nanoparticles, and other applications where hydrophilicity is important.
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DC33860 Sulfo-Cyanine 7 NHS ester
Sulfo-Cyanine7 is an improved analog of Cy7 fluorophore with higher quantum yield and photostability. This fluorescent dye is especially useful for NIR imaging. Sulfo-Cyanine7 NHS ester reagent allows to prepare sulfo-Cyanine7-labeled biomolecules, such as proteins, with ease. Dye labeled molecules can be subsequently used for various research and drug design related experiments.
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DC33851 borondipyrromethene TR NHS ester
BDP TR is a bright and photostable borondipyrromethene dye, which is especially suitable for microscopy applications. The dye has a long excited state lifetime, and is therefore is useful for fluorescence polarization assays. Its large two-photon cross section makes this dye useful for two-photon spectroscopy. This NHS ester is an amine-reactive form of the dye.
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DC33782 Disodium nitrilotriacetate
Disodium nitrilotriacetate is solid used as a chelating agent, which forms coordination compounds with metal ions (chelates) such as Ca2+, Cu2+, and Fe3+.
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DC33781 Kinsenoside
Kinsenoside is a glycoside with antihyperlipidemic, immunosuppressive, and anti-inflammatory properties. It raises lipolysis mediated by adipose triglyceride lipase and increases hydrolysis of triglycerides in C3H10T1/2 adipocytes.
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