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Novel inhibitors

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Cat. No. Product Name Field of Application Chemical Structure
DC36163 AI3-52333
Gibbs reagent is a universal thin-layer chromatographic visualization reagent.
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DC36147 Triphenyltetrazolium bromide
Triphenyltetrazolium bromide may be useful in the detection of experimental cerebral infarction and biochemical analysis.
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DC36134 Thioperamide
Thioperamide is an HRH4 antagonist and selective HRH3 antagonist capable of crossing the blood–brain barrier. Thioperamide negatively regulates the release of histamine and enhances the activity of histaminergic neurons by blocking autoreceptors. Its action on H3 is thought to promote wakefulness and improve memory consolidation.
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DC36116 AG-1777
Lansoprazole sulfide is an impurity of Lansoprazole -- a gastric pump inhibitor.
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DC36110 IMS2186
IMS2186 is an anti-proliferative and anti-angiogenic agent. IMS2186 blocks the cell cycle at G2 and inhibits the production of PGE2/TNF-α. IMS2186 inhibits cell growth in vitro in tumor cells, non-transformed fibroblasts, and retinal pigment epithelial cells. IMS2186 inhibits angiogenesis (IC50 = 0.1 μM) and cell migration. Intraocular injection of IMS2186 could be a long-lasting effective treatment for CNV (choroidal neovascularization) in AMD (age-related macular degeneration) with a reduction in scarring and related visual loss.
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DC36102 Aciclovir EP Impurity F
N2-Acetylaciclovir, also known as Aciclovir EP Impurity F, is an impurity of Aciclovir.
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DC36056 Aminoform
Methenamine is an anti-infective agent most commonly used in the treatment of urinary tract infections. Its anti-infective action derives from the slow release of formaldehyde by hydrolysis at acidic pH.
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DC35960 Ms-PEG8-Ms
Ms-PEG8-Ms is a PEG Linker.
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DC35926 PEG5-bis(phosphonic acid diethyl ester)
PEG5-bis(phosphonic acid diethyl ester) is a PEG Linker.
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DC35921 Propargyl-PEG3-phosphonic acid ethyl ester
Propargyl-PEG3-phosphonic acid ethyl ester is a PEG Linker.
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DC35873 m-PEG5-succinimidyl carbonate
m-PEG5-succinimidyl carbonate is a PEG Linker.
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DC35848 Bis-Mal-PEG3
Bis-Mal-PEG3 is a PEG derivative containing a two maleimide groups. The maleimide groups will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The hydrophilic PEG spacer increases solubility in aqueous media.
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DC35700 Azido-PEG3-CH2CO2-NHS
Azido-PEG3-CH2CO2-NHS is a PEG Linker.
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DC35680 Ald-CH2-PEG3-azide
Ald-CH2-PEG3-azide is a crosslinker containing an azide group and an aldehyde group. The azide group enables PEGylation via Click Chemistry. The hydrophilic PEG spacer increases solubility in aqueous media. The aldehyde group reacts with amines and the N-terminal of peptides and proteins to form an imine containing a C=N double bond, which can be further reduced. PEG aldehyde or ketone derivatives can be used in reversible PEGylation through its reaction with hydrazine or hydrazide forming a hydrolytic acyl hydrozone linkage.
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DC35629 Sulfo-NHS
Sulfo-NHS is a chemical modification reagent for converting carboxyl groups to amine-reactive NHS esters for bioconjugation, crosslinking, labeling and immobilization methods.
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DC35617 diethyl 7-bromoheptylphosphonate
diethyl 7-bromoheptylphosphonate is a PEG Linker.
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DC35589 m-PEG3-4-nitrophenyl carbonate
m-PEG3-4-nitrophenyl carbonate is a PEG derivative.
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DC35579 m-PEG13-Ms
m-PEG13-Ms is a PEG Linker
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DC35569 m-PEG4-CH2-aldehyde
m-PEG4-CH2-aldehyde is a PEG derivative containing an aldehyde group. Aldehyde is reactive to hydrazide and aminooxy groups which are commonly used in biomolecular probes for labeling and crosslinking carbonyls (oxidized carbohydrates). The hydrophilic PEG spacer increases solubility in aqueous media.
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DC35556 m-PEG6-azide
m-PEG6-azide is a PEG derivative containing an azide group. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The hydrophilic PEG spacer increases solubility in aqueous media.
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DC35533 m-PEG1-NHS ester
m-PEG1-NHS ester is a PEG derivative containing an NHS ester. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The hydrophilic PEG spacer increases solubility in aqueous media.
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DC35531 m-PEG9-CH2COOH
m-PEG9-CH2COOH is a PEG derivative containing a terminal carboxylic acid. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media.
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DC35512 Tri(t-butoxycarbonylethoxymethyl) ethanol
Tri(t-butoxycarbonylethoxymethyl) ethanol is a branched PEG derivative with a terminal hydroxy group and three t-butyl esters. The hydroxy group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl groups can be deprotected under mild acidic conditions.
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DC35477 Tr-PEG3
Tr-PEG3 is a PEG derivative.
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DC35466 m-PEG3-(CH2)3-alcohol
m-PEG3-(CH2)3-alcohol is a PEG derivative containing a hydroxyl group. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The hydrophilic PEG spacer increases solubility in aqueous media.
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DC35439 PEG8-Tos
PEG8-Tos is a PEG derivative containing a hydroxyl group with a tosyl group. The PEG linker contains 7 units of ethylene glycol. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The tosyl group is a very good leaving group for nucleophilic substitution reactions.
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DC35227 m-PEG8-bromide
m-PEG8-bromide is a PEG derivative. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media.
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DC35172 N-Boc-PEG4-alcohol
N-Boc-PEG4-alcohol is a PEG derivative containing a hydroxyl group and Boc-protected amino group. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The Boc group can be deprotected under mild acidic conditions to form the free amine.
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DC35155 t-Boc-N-amido-PEG2-CH2CO2H
t-Boc-N-amido-PEG2-CH2CO2H is a PEG derivative containing a terminal carboxylic acid and Boc-protected amino group. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
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DC35143 Bis-PEG9-NHS ester
Bis-PEG9-NHS ester is a PEG derivative containing two NHS ester groups. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. PEG Linkers may be useful in the development of antibody drug conjugates.
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