Novel Neuropeptide Y Y4 Receptor (Y4R) Antagonist (pK i values <7.57)

Novel E-Selectin antagonist, disrupting cell survival pathway activation, enhancing chemotherapy response and protecting from toxicity such as mucositis with improved survival in vivo

Novel potent antagonist of the Urotensin-II (UT) receptor

Novel superagonist of the urotensin-II (UT) receptor

Novel Potent antagonist of the Urotensin-II (UT) Receptor

Novel superagonist of the urotensin-II (UT) receptor

Potent kynurenine 3-monooxygenase (kynurenine 3-hydroxylase; KMO) inhibitor

The first bifunctional (chemoreactive and clickable) probe for Adenosine A1 and A3 Receptors

Novel β-arrestin-biased D2 receptor (D2R) agonist

Novel potent and selective PAM of CBX8, blocking H3K27me3 binding and enhancing CBX8 affinity for nucleic acids, evicting PRC1 from H3K27me3 targets triggering DLBCL cell differentiation

Novel inhibitor for histone methyllysine reader proteins (KmeRP), targeting CBX5 chromodomain

Novel peptidomimetic antagonist of the PHF1 Tudor domain, binding both PHF1 Tudor domain and the related protein PHF19

Novel inhibitor for histone methyllysine reader proteins (KmeRP), targeting CBX5 chromodomain

Novel inhibitor for histone methyllysine reader proteins (KmeRP), targeting CBX5 chromodomain

Novel selective activator of PRC2-EED-I363M, showing minimal effects on the activity of PRC2-WT

Novel selective activator of PRC2-EED-I363M, showing minimal effects on the activity of PRC2-WT

Novel allosteric inhibitor of PRC2 catalytic activity

Novel allosteric inhibitor of PRC2 catalytic activity

Novel Ligand of EEDm acting as an allosteric inhibitor of PRC2

Orally Active Adenosine A 1 Receptor Agonist

Negative control for UNC1666 which is a dual Mer and Flt-3 tyrosine kinase inhibitor

Novel Peptide Inhibitor for Calcium and Integrin Binding Protein 1 (CIB1)

Novel inhibitor of ROP18, inhibiting ROP18 within cells, and abrogating its effects on the host IRG pathway

Novel MYC protein stablizer, increasing the abundance of endogenous MYC proteintargeting the receptor tyrosine kinases KIT and platelet-derived growth factor receptor α (PDGFRα)

Biotinylated UNC0638, enabling chemiprecipitation of G9a from whole cell lysates

Novel nonhematotoxic DNA intercalating agent with potent antitumor activity, inducing apoptosis via inhibition of key proteins in the PI3K/Akt/mTOR signaling pathway

Novel fluorescent UnaG ligand, binding UnaG with high affinity (Kd = 3 nM) to induce a 2.5-fold fluorescence intensity enhancement and a 10 nm red shift

Novel anti-virulence agent, rescuing nematodes from a Staphylococcus aureus infection and preventing the formation of biofilm in a dose-dependent manner without interfering with bacterial viability

Novel Potent and Selective Dual Bromodomain 4 (BRD4)/Polo-like Kinase 1 (PLK1) Inhibitor

Novel, Potent, and Selective CBP/P300 Inhibitor