Novel, Potent, Selective, Water Soluble, Brain-Permeable EP2 Receptor Antagonist

Novel inhibitor of T315I mutant enzyme, exhibiting reasonable in vivo efficacy in a xenograft mouse model harboring T315I

Novel dual VEGFR/Src kinase inhibitor

Novel potent SARS coronavirus (CoV) 3CL protease inhibitor (Ki = 53 nM)

Novel and Potent Stem Cell Mobilizer; Inhibitor of SDF-1α/CXCR4 binding

Cyclized tamoxifen analog, selective ER modulator (SERM)

CNS-penetrant selective class IIa histone deacetylase (HDAC) inhibitor, exploiting the >100-fold selectivity over class I/IIb HDACs

Novel cell-active, selective class IIa HDAC inhibitor

Novel GSK-3β inhibitor, showing anti-neuroinflammatory effects in lipopolysaccharide (LPS) activation of spontaneously immortalized SIM-A9 microglial cells and of mouse cortical microglia, inhibiting LPS-induced production of nitric oxide and the proinfla

Novel multipotent anti-Alzheimer agent, selectively inhibiting human butyrylcholinesterase (BChE), having strong antioxidant activity and good β-amyloid (Aβ) anti-aggregation properties

Novel endothelin (ET) receptor antagonist

Potent and selective human leukocyte 5-lipoxygenase (5-LOX) inhibitor

Antitubercular agent

Inducer of S phase arrest and apoptosis in hepatocellular carcinoma QGY-7701

Potent inhibitor of protein synthesis, inhibiting translation by binding within the ribosomal exit tunnel

Activator of the hepatic interferon pathway in rats

Reversible inhibitor of vesicular monoamine transporter 2, showing anti-chorea effect and decreasing uptake of monamines into synaptic vesicles, as well as depletion of monoamine storage

Mutually Orthogonal Bioorthogonal Amino Acid, Enabling Efficient Protein Dual-Labeling in Cells

Selective Thromboxane_receptor>thromboxane receptor antagonist

Peptide vaccine, residues (611-626) of the human telomerase reverse transcriptase catalytic subunit (hTERT), for the treatment of solid cancers

COX/5-LOX inhibitor and cytokine-modulating anti-inflammatory agent

Photosensitizing agent used in the treatment of squamous cell carcinoma of the head and neck, also showing activity agaimst COVID-19 Mpro

Mucolitic agent, inhibiting activation of nuclear factor kappa-κB (NF-κB) by blocking phosphoinositide 3-kinase/protein kinase B (PI3K/Akt)/IκB kinase (IKK) activities, showing the anti-inflammatory properties on inflammation-associated skin diseases

Potent and selective M1 antimuscarinic

Natural antibacterial agent, being active against gram-positive bacteria.

Novel monocyte/macrophage targeted histone deacetylase inhibitor

Novel antimalarial agent

Novel inhibitor of the p53-Hdm2 protein-protein interaction, dose-dependently stabilized P53 and increased P21 and MDM2 expression in JAR choriocarcinoma cells, inducing the p53 regulated gene (PIG-3) and caspase activity

Novel potent inhibitor of tyrosyl-DNA phosphodiesterase 1 (Tdp1)

Novel Specific Copper Chelator, Reducing Memory Impairments in Alzheimer's Disease Mouse Models