Novel inhibitor of protein-protein interaction (PPI), targeting integrin αvβ3-osteopontin interface, blocking OC maturation from murine bone marrow-derived macrophages, as well as the resorptive function of OCs, impairing downstream signaling of integrin

Irreversible and nonselective Monoamine_oxidase_inhibitor>monoamine oxidase inhibitor (MAOI)

Inhibitor of the uPAR·uPA protein-protein interaction, blocking cancer cell invasion

Novel inhibitor of glioblastoma multiforme (GBM), inhibiting cell viability of low-passage patient-derived GBM spheroids, blocking tube-formation of endothelial cells in Matrigel, showing no effect on primary hematopoietic CD34+ progenitor spheroids or as

Natural inhibitor of the in vitro biogenesis of the SARS-CoV-2 spike protein and its host cell membrane receptor, binding Sec61α to Inhibit Protein Translocation

Natural toxic furanoterpenoid found in mold-damaged sweet potatoes

Orally bioavailable inhibitor of Hedgehog signaling, inhibiting tumor initiation and metastasis in pancreatic cancer

Muscarinic Acetylcholine Receptor Hybrid Ligand, possessing noticeable M2/M4 mAChR selectivity

Novel inhibitor of the plant inositol phosphorylceramide synthase ((IPCS), demonstrating herbicidal activity

Selective monoamine oxidase A inhibitor

Novel antifungal agent, exhibiting broad spectrum and potent activity against 12 kinds of clinically pathogenic fungi

Novel Potent Fungal-Selective Inhibitor of Mitochondrial Cytochrome bc1

Natural Activator of Programmed Cell Death, leading to membrane damage, mitochondria alteration, chromatin condensation, and ROS accumulation

Inhibitor of both topoisomerase I and II via intercalating DNA helix

Natural potent inhibitor of H. pylori DHODH, having greater efficacy for treatment of H. pylori infection

Blocker of the interaction of FAK and IGF-1R; Antagonist of the phosphorylation of tumor AKT

Activator of the P2Y6 receptor in bone, increasing survival of osteoclasts

Novel inhibitor of the DNA-binding domain (DBD) of STAT3, suppressing tumor growth, metastasis and STAT3 target gene expression in vivo

Novel potent inhibitor of DDR1 tyrosine kinase

Novel putative inhibitor of type III secretion (T3S) in the Gram-negative pathogen Yersinia pseudotuberculosis and Chlamydia trachomatis

Novel Potent and Orally Active Inducible Nitric Oxide Synthase (iNOS) Dimerization Inhibitor with Efficacy in Rheumatoid Arthritis Mouse Model

Novel Potent and Selective Inducible Nitric Oxide Synthase (iNOS) Inhibitor (IC50 = 74 nM) with high BBB permeability (Pe = 19.1 × 10-6 cm/s) for Parkinson's Disease

Novel selective inhibitor of the iNOS, without affecting the eNOS isoform

Novel Potent Inhibitor of Microbiome ß-Glucuronidases

Novel Potent Inhibitor of Microbiome ß-Glucuronidases

Novel dual inhibitor of MAPKAPK5 and MAPKAPK2

Novel inhibitor of Ark1, the fission yeast member of the conserved Aurora kinase family

Novel inhibitor of the influenza virus reproduction, inhubiting the formation of the virus specific hemagglutinin

NIR emitting firefly luciferin analogue

Metabolite of tryptophan, showing adverse effects on bones and the central nervous system, having been most frequently implicated as a contributor to renal disease progression and vascular disease