Novel sPLA2 inhibitor, suppressing murine endotoxic shock and LDL modification, blocking binding to the M-type receptor

Topoisomerase I (Top1) inhibitor

Novel inhibitor of dihydroorotate dehydrogenase (DHODH), promoting myeloid differentiation and inhibiting the proliferation of acute promyelocytic leukemia HL-60 cells, also suppressing cell growth in various other types of cancer cells

Natural antibiotic, selectively inhibiting bacterial tryptophanyl-tRNA synthetase (TrpRS)

Metabolite of tryptophan, reducing the interleukin-8 (IL-8) response after IL-1β stimulus, interacting with the transcription factor aryl hydrocarbon receptor (AHR) and preventing transcription of the inflammatory cytokine IL-8, being anti-inflammatory in

Platelet aggregation inhibitor acting as a reversible Cyclooxygenase>cyclooxygenase inhibitor

Topoisomerase I (Top1) inhibitor

Antidepressant and cerebral activator, acting as a serotonin releasing agent, norepinephrine reuptake inhibitor, and NMDA receptor antagonist, enhancing acetylcholine release via activation of the 5-HT4 receptor

Selective estrogen receptor modifier (SERM), being a selective ERß agonist

Antiprion agent, reducing PrP(Sc) levels in dividing and stationary-phase cells

Novel selective inhibitor of PfHsp90, bypassing its highly similar human orthologs

Novel selective Mtb-DHFR inhibitor as an antimycobacterial agent

Novel potent and selective lysine-specific demethylase 1 (LSD1) inhibitor

Janus-associated kinase (JAK) inhibitor

Novel ALK5 inhibitor

Potent inhibitor of the TGF-β type I receptor activin receptor-like kinase 5 (ALK5)

Mtb growth inhibitor, inhibiting Mtb GlgB activity by interacting to its active site residues

Novel plant immune-priming agent, acting as a partial agonist of salicylic acid

Novel plant immune-priming agent, acting as a partial agonist of salicylic acid

First in-class allosteric inhibitor of a bacterial IMPDH, showing to counteract the activation by the natural positive effector, MgATP, and to block the enzyme in its apo conformation

Novel Probe for NLRP3 Inflammasome Inhibitor MCC950

Novel cell-active and potent inhibitor of bacterial DNA repair, potentiating quinolone antibiotic activity in methicillin-resistant Staphylococcus aureus

Novel resistance breaking antimalarial N-myristoyltransferase (NMT) inhibitor, binding to NMT peptide binding pocket

Novel potent inhibitor of BV2 microglia activation, protecting PC12 cells and primary neurons against indirect toxicity mediated by exposure to conditioned medium (CM) from LPS-treated BV2 cells

Insect neurotoxin, blocking nicotinic acetylcholine receptors and preventing acetylcholine from transmitting impulses between nerves

BCL2 i-motif-interactive compound, destabilizing or unfolding the i-motif

BCL2 i-motif-interactive compound, stabilizing or facilitating the folding of the i-motif

Novel inhibitor of protein kinase B (PknB), inhibiting PknB auto-phosphorylation and the phosphorylation of GarA by PknB in a dose-dependent manner

Novel anti-tuberculosis agent, targeting Mycobacterial tuberculosis (Mtb) aspartate semialdehyde dehydrogenase

Novel orally effective direct renin inhibitor for treating diabetic nephropathy and hypertension