First-in-Class, Potent, and Orally Bioavailable NADPH Oxidase Isoform 4 (Nox4) Inhibitor

Natural Activator of the Nrf2-Regulated Antioxidant Defense System in SH-SY5Y Cells, Binding to the Subpockets of Keap1 Kelch Domain

Natural suppressor of mesenchymal stem cell (MSC) differentiation

Novel suppressor of endoplasmic reticulum (ER) stress and oxidative stress, preventing protein aggregate accumulation in vitro and in cultured hippocampal HT22 neuronal cells, as well as glutamate-induced oxytosis and erastin-induced ferroptosis

Novel suppressor of endoplasmic reticulum (ER) stress and oxidative stress, preventing protein aggregate accumulation in vitro and in cultured hippocampal HT22 neuronal cells, as well as glutamate-induced oxytosis and erastin-induced ferroptosis

Potent mitochondrial benzodiazepine receptors (MBRs) ligand; Prodrug for its active metabolite bromo-nordazepam

Novel oral anti-nociceptive agent, showing peripheral opioid agonistic activity and hydrogen sulphide-releasing capacity

Potent EGFR/erbB2 dual inhibitor

Metalloproteinase inhibitor, specifically blocking TNF-alpha secretion both in vitro and in vivo

Novel nonpeptidic inverse agonist of the Ghrelin Receptor (GHSR)

Endogenous dipeptide, activating N-methyl-D-aspartate receptors

Natural non-covalent NRF2 activator, activating NRF2 in A KEAP1-dependent but Cys151-independent manner, conferring greater protection than a Cys151-dependent analog, geopyxin C

Natural covalent Cys151-dependent NRF2 activator

Metabolite of ganstigmine, a novel acetylcholinesterase inhibitor

Novel antifungal agent

MAO inhibitor

Novel Phosphodiesterase 4D (PDE4D) Inhibitor

Inhibitor of the Wnt/beta-catenin signaling pathway, suppressing cell proliferation and enhancing radiosensitivity in A549/Wnt2 cells.

Novel SMAC mimetic and IAP antagonist

Novel Bruton's tyrosine kinase (BTK) inhibitor

Novel potent, selective and orally bioavailable Chk1 inhibitor

Novel highly-selective oral checkpoint kinase 1 (Chk1) inhibitor

Novel glucosylceramide synthase (GCS) inhibitor, rescuing lysosomal deficits, α-synuclein pathology and neuron toxicity

Novel Potent and Selective Sodium Glucose Co-Transporter 2 (SGLT2) Inhibitor for the Treatment of Type 2 Diabetes

Highly potent non-nucleoside inhibitor of HIV-1 reverse transcriptase

Selective inhibitor of carbonic anhydrase IX (CAIX)

Selective inhibitor of carbonic anhydrase IX (CAIX)

Novel non-toxic and mammalian-specific LINE-1 inhibitor

Antagonist of central cholecystokinin receptors

Novel CB1R allosteric agonist-positive modulator (ago-PAM), exhibiting augmented allosteric-agonist and PAM activities in neuronal cultures, improved metabolic stability, and enhanced orthosteric agonist binding (CP55940)