Novel potent natural STAT3 signaling inhibitor from Polygonum cuspidatum, inhibiting cell growth and inducing apoptosis of HCC cells and HCC Cancer stem cells.

Endogenous superagonist of transient receptor potential melastatin 2 (TRPM2)

Inhibitor of cellular glycosylation; Analytical standard

Site BI- selective synergistic activator of PKA I

Lipid mediator, regulates neuronal apoptosis in traumatic brain injury (TBI)

Metabotropic Glutamate Receptor 5-selective Negative Allosteric Modulator

Novel potent activator of both human and mouse TLR4-NF-κB reporter cells and primary cells, inducing serum anti-HA and anti-NA IgG1 levels

Novel GPR88 Agonist

Novel selective inhibitor of EGFR kinase, leading to inactivation of PI3K/AKT/mTOR and Ras-Raf-MEK-ERK signal pathways

Novel Selective LXRβ Agonist

Oxysterol agonist of the liver X receptor

Novel Versatile Probe for Interrogating Histone Benzoylation and Interactions in Living Cells

Stimulator of the central nervous system, decreasing the 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) levels in brain

Concentration- and time-dependent inhibitor of the growth of NSCLC cells inducing apoptosis

Inhibitor of SykM442A S505A ASKA- (analog-sensitive kinase alleles) mediated cellular calcium flux

Natural Inhibitor for FcεRI expression on mast cell from Verbasucum thapsus L

Novel potent antiangiogenic agent, binding to VEGFR2, significantly reducing neovascularization in both ex vivo and in vivo angiogenic assays without affecting the proliferation of endothelial cells

Novel inhibitor of thioredoxin reductase (TrxR)

inactive isomeric impurity of Alphacalcidol

The first organic NO2-containing molecule isolated from plants, stimulating the soluble guanylate cyclase-cGMP pathway

Building Block

Building Block

Building Block

Reporter molecule functionalized at the anomeric position, exhibiting robust labeling over background with negligible amounts of nonspecific chemical labeling in cell lysates

Reporter molecule functionalized at the anomeric position, exhibiting robust labeling over background with negligible amounts of nonspecific chemical labeling in cell lysates

Strong growth inhibitor as an antimetabolite

Highly potent inhibitor of Wnt/βcatenin signaling in melanoma cells, coordinately inhibiting cell proliferation and disrupts expression of Microphthalmia Associated Transcription Factor isoform M, also inhibiting NEDD4-1

Novel Neuroprotective GSK-3β Inhibitor, highly selectively inhibiting HIV-1; The second generation derivative of 6BIO

Novel inhibitor of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1), being highly selective over 17β-HSD2

Novel potent inhibitor of 17ß-hydroxysteroid dehydrogenase type 2 (17ß-HSD2)