Aminopyridine 2 (MPO inhibitor AP-2) is a novel potent, selective, orally available inhibitor of Myeloperoxidase (MPO), inhibits MPO peroxidase activity in vitro and in human plasma with IC50 of 0.16 and 1.9 uM, respectively.

Aminopeptidase N (AP-N) inhibitor is a reversible inhibitor of AP-N/CD13 (IC50 = 25 μM).

Aminoglutethimide is an aromatase inhibitor with IC50 of 10 μM.

Amikacin is an aminoglycoside antibiotic used to treat different types of bacterial infections.

Amidopyrine is white crystalline substance used as an analgesic and antipyretic.

Amicarbazone(BAY-MKH3586; BAY314666) is a potent inhibitor of photosynthetic electron transport via binding to the Qb domain of photosystem II (PSII); herbicide with a broad spectrum of weed control.

AMG7703 (4-CMTB, AMG-7703) is an allosteric, selective agonist of FFAR2 (GPR43)..

AMG-458 (AMG458) is a potent, selective, orally bioavailable c-Met inhibitor with Ki of 1.2 nM (human c-Met).

AMG1694 is a potent, small molecule Glucokinase (GK)-GKRP (GK regulatory protein) disruptor, does not block the GK binding site directly.

AMG-076 is a potent, selective, non-peptide antagonist of MCHR1 (Melanin-concentrating hormone receptor 1) with binding IC50 of 0.6 nM, with dramatically reduced hERG liability (IC50>5 uM).

AMG 837 calcium hydrate is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents.

Ametantrone is a new anthracenedione antineoplastic agents, produced a concentration-dependent inhibition of hepatic microsomal lipid peroxidation.

Amelubant (BIIL284) is a potent, long-acting, orally active leukotriene B4 (LTB4) receptor antagonist, inhibits LTB4-induced mouse ear inflammation with ED50 of 0.008 mg/kg (p.o.).

Amantadine Hydrochloride is an antiviral and an antiparkinsonian drug.

AM679 is a potent and selective FLAP inhibitor with IC50s of 2.2 nM/0.6 nM/154 nM for FLAP binding/hLA/hWB respectively.

AM-6226 (AM6226) is a potent, selective, orally bioavailable GPR40 (FFA1) full agonist with EC50 of 0.12 uM.

AM-5262 is a potent full GPR40 (FFA1) agonist with EC50 of 81 nM.

ALW-II-49-7 (DDR2-IN-1) is a potent, selective DDR2 inhibitor with IC50 of 18.6 nM, also shows ability to inhibit DDR1 and Ephrin-family kinases (IC50=40 nM for EphB2).

Alverine citrate is a drug used for functional gastrointestinal disorders.

Altretamine (Hexalen)

ALS-8176 (Lumicitabine) is the 3',5'-di-O-isobutyryl prodrug of ALS-8112 5'-triphosphate (ALS-8112-TP), which is a potent, selective RSV polymerase inhibitor with IC50 of 20 nM.

ALS-8112 is a potent, selective RSV polymerase inhibitor, the 5'-triphosphate of ALS-8112 (ALS-8112-TP) inhibits RSV polymerase(IC50=20 nM) without appreciable inhibition of human DNA and RNA polymerases.

Alprazolam (D-65MT, U 31889) is a triazolobenzodiazepine agent with anxiolytic, sedative-hypnotic and anticonvulsant activities.

Alogliptin

Almotriptan

all-trans-4-Oxoretinoic acid, an active metabolite of vitamin A, induces gene transcription via binding to nuclear retinoic acid receptors (RARs).

Alloxazine is an A2 receptor antagonist, which is approximately 10-fold more selective for the A2B receptor than for the A2A receptor.

Allopurinol (Zyloprim) is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM.

Alloepipregnanolone, a pregnane with anesthetic, hypnotic, and sedative properties, interferes with the development of rapid tolerance to the anxiolytic effect of ethanol.

Alizarin has a selective and effective inhibitory activity towards cancerous cells, it acts through the inhibition of ERK phosphorylation and cell cycle arrest in the S-phase.