Potent, selective, and brain penetrating H2 receptor antagonist

Inducer of functional angiogenesis through increased H 2 S availability

Novel antidiabetic agent for the treatment of type 2 diabetes mellitus (DM)

Potent, selective inhibitor of Janus tyrosine kinase 3 (JAK3)

Potassium channel opener

Selective nonpeptide, NK-2 receptor (NK-2R) antagonist

K-Channel opener (PCO) activating predominantly KATP channels in vitro to relax bladder detrusors

5-Lipoxygenase (5-LO) inhibitor

Non-steroidal pure antioestrogen

ATP-sensitive potassium channel-blocker; Eukalemic diuretic

Novel potent and highly selective inhibitor of wild-type and mutant versions of EZH2

Novel β-catenin/B-cell lymphoma 9 (BCL9) inhibitor, disrupting the β-catenin/BCL9 protein-protein interaction (PPI) with a Ki of 0.96 μM and without affecting the β-catenin/E-cadherin interaction in living cells, displaying good selectivity for β-catenin/

Novel potent and selective BRD4 bromodomain 1 (BD1) inhibitor

Novel potent and selective BRD4 bromodomain 1 (BD1) inhibitor

Novel dual mordulator of nNOS-PSD-95 interaction and GABA A receptor

Novel potent inhibitor of factor Xa (FXa)

Novel oral multitarget tumour growth inhibitor

Type III progesterone receptor antagonist with enhanced antiproliferative properties

Non-competitive AMPA receptor antagonist

Cell-permeable fluorometric zinc sensor

Novel ASCT2 inhibitor

Novel potent and specific inhibitor of the UNC119-Src interaction, binding to UNC119 in cells, and inducing redistribution of Src to endomembranes and reduction of activating Src autophosphorylation on Y419

Novel gp120 of HIV-1 Antagonist

Novel CtpF inhibitor, inhibiting Ca -dependent ATPase activity in Mtb membrane vesicles

Novel Zika virus RNA polymerase inhibitor

Novel blocker of AKT1-FAK interaction, reducing the stimulation of FAK phosphorylation in response to extracellular pressure in human SW620 colon cancer cells without affecting basal FAK phosphorylation

Novel Nef Protein Inhibitor; Anti-HIV

Potent Ebolavirus (EBOV) Inhibitor

Novel GDNF Family Receptor Agonist

Novel EGFR triple mutant T790M/C797S allosteric inhibitor