SRT1460 is a potent, selective SIRT1 activator with EC1.5 of 2.9 uM, displays good selectivity for activation of SIRT1 versus SIRT2 and SIRT3 (EC1.5>300 uM) and is more potent than Resveratrol.

SRT 2183 is a potent, selective SIRT1 activator with EC1.5 of 0.36 uM, displays good selectivity for activation of SIRT1 versus SIRT2 and SIRT3 (EC1.5>300 uM) and is more potent than Resveratrol.

SRPIN-803 (SRPIN 803, SRPIN803) is a novel small molecule dual inhibitor of SRPK1 and CK2 with IC50 of 2.4 uM and 0.2 uM, respectively, does not inhibit SRPK2.

SRI-31142 (SRI31142) is a novel potent, putative allosteric dopamine transporter (DAT) inhibitor with Ki of 1.9 nM..

SRI 37892 (SRI37892) is a novel potent, small molecule Frizzled 7 (Fzd 7) inhibitor with IC50 of 0.66 uM in Wnt/β-catenin assay.

SR7826 is a potent and selective LIM kinase (LIMK) inhibitor with IC50 of 43 nM, displays >100-fold selectivity over ROCK1 and ROCK2, as well as JNK kinases (>400-fold).

SR-57227 is a high affinity, selective 5-HT3 receptor agonist, demonstrates anticonvulsant effects in vivo..

SR-57227 is a high affinity, selective 5-HT3 receptor agonist, demonstrates anticonvulsant effects in vivo..

SR-3306 is a highly selective, brain penetrant, potent inhibitor of JNK with IC50 of 67, 283 and 159 nM for JNK1, JNK2 and JNK3, >100-fold selectivity over p38.

SR-20295 (SR20295) is a novel potent ULK1 inhibitor with IC50 of 45 nM..

SR-16835 is a potent full agonist of ORL1 receptor (NOP receptor) with binding Ki of 11.4 nM, with low-affinity mu-opioid partial agonist activity (Ki=79.9 nM).

SR-16435 is a mixed NOP/μ-opioid partial agonist with equally high affinity (Ki=29 nM) for both NOP and μ-opioid receptors.

SR-16430 is a selective ORL1 receptor (NOP receptor) antagonist that has 10-fold selectivity over μ-opioid receptor..

SR146131 (SR-146131) a small molecule positive allosteric modulator of the type 1 cholecystokinin receptor (CCK1R) with pEC50 of 10.34..

SR-14150 is a potent NOP/μ-opioid partial agonist with Ki of 1.39 nM and 29.9 nM, respectively.

SR12460 (SR-12460) is a novel NF-κB essential modulator (NEMO)-binding domain (NBD) mimetic for inhibiting IKK/NF-κB activation, inhibits TNF-α-mediated NF-κB activation with IC50 of 20.24 uM.

SR12343 (SR-12343) is a novel NF-κB essential modulator (NEMO)-binding domain (NBD) mimetic for inhibiting IKK/NF-κB activation, inhibits TNF-α-mediated NF-κB activation with IC50 of 11.34 uM in luciferase assays.

SR1001 is a high-affinity synthetic ligand of RORα and RORγ; suppresses TH17 cell differentiation and inhibits autoimmunity.

SR 9444 is a small molecule bidentate-binding dual inhibitor probe of the LRRK2 and JNK with IC50 of 12 nM and 99 nM respectively.

SR 16832 is a dual-site covalent antagonist of peroxisome proliferator-activated receptor γ (PPARγ).

Squalene epoxidase inhibitor. Suppresses triglyceride biosynthesis through the farnesol pathway.

SPX-101 is a specific, peptide mimetic promoter of epithelial sodium channel (ENaC) internalization, binds selectively to ENaC and promotes internalization of the α-, β-, and γ-subunits.

SPV 106 is the first mixed activator/inhibitor of Histone acetyltransferases (HATs), potentiates p300/CBP-associated factor (PCAF) HAT activity while inhibiting those of p300/CBP and recombinant CBP.

SPRi3 (SPR inhibitor 3) is a small molecule inhibitor of sepiapterin reductase (SPR) with IC50 of 74 nM in cell-free assays, efficiently reduces biopterin levels with IC50 of 5.2 uM.

SPR-00305 is a potent MvfR inhibitor and displays target engagement.

SPOP-IN-6b is a potent, small-molecule E3 Ligase adaptor SPOP (speckle-type POZ protein) inhibitor that inhibits the SPOP-substrate protein interaction with IC50 of 35 uM (inhibits puc-SBC1 peptide binding to SPOP).

sPLA2-X inhibitor 31 is a potent, selective secreted phospholipase A2 type X (sPLA2-X) with IC50 of 26 nM, displays 12-fold and 80-fold selectivity over sPLA2-Iia and sPLA2-V, respectively.

SPL-707 (SPL707) is the first selective, orally active signal peptide peptidase-like 2a (SPPL2a) inhibitor with IC50 of 77 nM, shows 25-fold selectivity over γ-secretase and SPP.

SPK-601(LMV-601) is a potent phosphatidylcholine-specific phospholipase C (PC-PLC) inhibitor; SPK-601 is useful antimicrobial agent.

Spiropiperidine 1 (SPP1)i s a potent, functionally selective and brain penetrant M1 orthosteric agonist with Ki of 21.3 nM for hM1 receptors.