Novel dual inhibitor of dihydrofolate reductase (DHFR) and its functional analog, Rv2671

Stereoisomer of UCN-01, inhibiting protein kinase C with a slightly reduced potency than UCN-01

Dual inhibitor of fatty acid amide hydrolase (FAAH) and α/β hydrolase domain 6 (ABHD6)

Novel potent isoprenylcysteine carboxylmethyltransferase (ICMT) inhibitor, improving survival in Ras-driven acute myeloid leukemia

Novel Agonist of the Type 1 Lysophosphatidic Acid Receptor (LPA1), Showing Efficacy in Neuropathic Pain Amelioration

The first potent nonimidazole H3 receptor antagonist (pKi=8.40)

Histamine H3 Receptor Antagonist in Treatments of Cognition Disorders

Novel non-competitive UCK2 inhibitor, suppressing nucleoside salvage in cells both in the presence and absence of DHODH inhibitors

Novel non-competitive UCK2 inhibitor, suppressing nucleoside salvage in cells both in the presence and absence of DHODH inhibitors

Novel non-competitive UCK2 inhibitor, suppressing nucleoside salvage in cells both in the presence and absence of DHODH inhibitors

Competitive dual inhibitor of the hydrolysis FS-3 and the phosphodiesterase substrate p-nitrophenyl thymidine 5'-monophosphate

Selective competitive inhibitor of ATX-mediated hydrolysis of the lysophospholipase substrate FS-3

Selective competitive inhibitor of ATX-mediated hydrolysis of the lysophospholipase substrate FS-3

Novel allosteric modulator of neonatal Fc receptor (FcRn), binding to the extracellular domain of FcRn

Novel inhibitor of TNF signalling by stabilising an asymmetric form of the trimer, displaying a concentration-dependent response curve and selectivity over the TNFR1 extracellular domain and control proteins

Novel inhibitor of TNF signalling by stabilising an asymmetric form of the trimer, displaying a concentration-dependent response curve and selectivity over the TNFR1 extracellular domain and control proteins

Potent ligand of synaptic vesicle protein 2A (SV2A)

Modulator of cyclic AMP generation, amplifing induced cyclic AMP formation in rat brain tissue; Nootropic

Novel Antagonist of the USP5 Zinc Finger Ubiquitin-Binding Domain (USP5 ZnF-UBD)

Novel NMDAR positive allosteric modulator (PAM), robustly potentiating responses at all GluN1/GluN2 subtypes and at neuronal NMDARs

Novel pan potentiator of GluN1/GluN2 receptors

Novel pan-inhibitor of GluN1/GluN2 receptors

Selective modulator of NMDA_receptor>NMDA receptors, potentiates responses at GluN1/GluN2A

Novel potent and broad-spectrum antiviral agent against multiple strains of EV-D68, EV-A71, and CVB3, targeting the viral protein 2C

Novel potent inhibitor of microtubule polymerization, binding directly to tubulin α/β heterodimers via the colchicine-binding site, perturbing mitotic spindles, delaying cells in mitosis and promotes apoptosis

Potent and selective dopamine D4 receptor antagonist

Novel competitive inhibitor of tyrosinase enzyme

Stable analog of phosphotyrosine (pTyr)

First-in-class selective PRMT5 inhibitor, blocking EBV-driven B lymphocyte transformation and survival while leaving normal B cells unaffected

Novel highly potent and selective TYK2 JH2 inhibitor, providing robust inhibition in a mouse IL-12-induced IFNγ pharmacodynamic model as well as efficacy in an IL-23 and IL-12-dependent mouse colitis model