Novel highly potent, selective, and CNS-penetrant inhibitor of elongation of very long chain fatty acid 1 (ELOVL1) enzyme

Novel γ-secretase inhibitor

Oleoylethanolamide-modelled PPAR

Novel ligand of the apelin receptor (APJ), possessing high affinity for APJ (Ki 4.6 nM) and producing cardiorenal effects in vivo similar to those of ELA

Novel inhibitor of Aurora B kinase

Novel etomidate analogue, enhancing GABA A receptors currents with a concentration for 50% of maximal effect (EC 50 ) of 0.98 {plus minus} 0.02 μM, which was about three times more potent than etomidate (3.07 {plus minus} 1.67 μM), retaining the favorable

Novel Cell-active Inhibitor of the Undrugged Oncogenic PTP4A3 Phosphatase

Novel Cell-active Inhibitor of the Undrugged Oncogenic PTP4A3 Phosphatase

Novel anti-bacterial agent, targeting the MmpL3 transporter in Mycobacterium abscessus

Novel RNA-competitive, ATP-uncompetitive eIF4A Inhibitor, decreasing BJAB Burkitt lymphoma cell viability, engaging a novel pocket in the RNA groove of eIF4A and inhibiting unwinding activity by interfering with proper RNA binding and suppressing ATP hydr

Novel water-soluble analog of progesterone, reducing cerebral edema and lesion size and improving functional recovery, decreasing glial fibrillary acidic protein expression immunoreactivity

Novel water-soluble analog of progesterone

Novel Mirk kinase inhibitor, inhibiting DYRK1A-induced Tau phosphorylation at multiple AD-relevant sites, blocking the in vivo growth of pancreatic cancer cells

Potent and bio-stable inhibitor of the chicken sEH (chxEH)

Potent and bio-stable inhibitor of the chicken sEH (chxEH)

Potent and bio-stable inhibitor of the chicken sEH (chxEH)

Arginase Inhibitor, activating EPO-mediated mitochondrial function and haemoglobin expression, stimulating melanogenesis by MAP kinase activation and tyrosinase upregulation

Antibacterial agent

Selective, non-competitive AMPA receptor antagonist, improving motor co-ordination

Potent inhibitor of adrenergic alpha1, alpha2c, 5-HT2a, 5HT7 receptors; Relatively selective blocker of adrenergic alpha2c over adrenergic alpha2a receptors.

Novel EGFR inhibitor, attenuating Ang II-induced Kidney Fibrosis

Novel EGFR inhibitor, significantly reducing myocardial inflammation, fibrosis, apoptosis, and dysfunction, showing promises to the treatment on obesity-induced cardiac complications

Novel EGFR inhibitor, attenuating Ang II-induced Kidney Fibrosis

Novel third-generation EGFR tyrosine kinase inhibitor, targeting EGFR T790M mutation in advanced non-small cell lung cancer

Antibiotic, inhibiting bacterial protein synthesis

Natural alpha-aminobutyric acid-rich secondary metabolite of fungi, strongly inhibiting the BBMV V-ATPase, acting as a mitochondrial complex V inhibitor, showing antitumor activity in vivo

Calcium channel blocker, blocking both T-type and L-type calcium channels

Potent agonist of peroxisome proliferator-activated receptor gamma (PPAR-gamma) with potential antineoplastic activity

Novel eEF2K inhibitor, inducing significant apoptosis through classical apoptotic pathways

An impurity of Edoxaban, a novel inhibitor of factor Xa