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Home > Inhibitors & Agonists > Metabolic Enzyme/Protease > Ser/Thr Protease

Ser/Thr Protease

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Cat. No. Product Name Field of Application Chemical Structure
DC48248 PCSK9-IN-1
PCSK9-IN-1 is a novel and highly potent cyclic peptide PCSK9 inhibitor with a Ki value of 1.46 nM.
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DC47927 PCSK9-IN-3
PCSK9-IN-3 is a novel, highly potent, and orally bioavailable next-generation tricyclic peptide PCSK9 inhibitor.
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DC47872 WNK-IN-11-d3
WNK-IN-11 D3 is an orally active, selective and potent With-No-Lysine (WNK) kinase inhibitor. WNK-IN-11 D3 is effective at regulating cardiovascular homeostasis.
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DC47337 PCSK9-IN-2
PCSK9-IN-2 is a novel small molecule inhibitor of PCSK9-LDLR protein–protein interaction (PPI) with an IC50 value of 7.57 μM.
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DC47297 SLN124
SLN124 is a GalNac-siRNA targeting transmembrane serine protease 6 (Tmprss6). SLN124 is composed of a trimeric GalNAc ligand conjugated to TMPRSS6‐siRNA. SLN124 has the potential for an siRNA to restore hepcidin expression and normalise iron homeostasis in β‐thalassaemia.
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DC47182 Tilpisertib
Tilpisertib is a serine/threonine kinase inhibitor (WO2017007689).
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DC47166 CRA-2059 TFA
CRA-2059 is a highly specific and selective tryptase inhibitor, with a Ki of 620 pM for recombinant human tryptase-β (rHTβ).
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DC46972 CRA-2059 hydrochloride
CRA-2059 hydrochloride is a highly specific and selective tryptase inhibitor, with a Ki of 620 pM for recombinant human tryptase-β (rHTβ).
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