VH 032 Linker 2 |CAS 2064292-52-8|DC Chemicals

Cas No.:	2064292-52-8
Chemical Name:	(S,R,S)-AHPC-PEG4-NH2 hydrochloride
Synonyms:	VH-03 linker; VH 03 linker; VH03 linker; VH03-linker,E3 ligase Ligand-Linker Conjugates 7
SMILES:	O=C([C@H]1N(C([C@H](C(C)(C)C)NC(COCCOCCOCCOCCN)=O)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2.[H]Cl
Formula:	C₃₂H₅₀ClN₅O₈S
M.Wt:	700.29
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
Publication:	[1]. Crew, Andrew P, et al. MDM2-BASED MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE. US20170008904A1.

Description:	E3 ligase Ligand-Linker Conjugates 7 is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology.
Target:	E3 Ligase Ligand-Linker Conjugate[1]
In Vitro:	E3 ligase Ligand-Linker Conjugates 7 is from patent US20170008904, example 3, 0376. E3 ligase Ligand-Linker Conjugates 7 is part of compound A1895[1].
References:	[1]. US20170008904

Cat. No.	Product name	Field of application
DC39625	(S,R,S)-AHPC-PEG4-NH2 hydrochloride	VH 032 Linker 2 is a derivative of the proteolysis-targeting chimera technology (PROTAC) building block VHL ligand 1.
DC50073	(S,R,S)-AHPC-PEG3-NH2 hydrochloride（E3 ligase Ligand-Linker Conjugates 5）	(S,R,S)-AHPC-PEG3-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology.
DC50071	(S,R,S)-AHPC-PEG2-NH2 hydrochloride E3 ligase Ligand-Linker Conjugates 6)	(S,R,S)-AHPC-PEG2-NH2 hydrochloride (VH032-PEG2-NH2 hydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs.
DC50053	E3 Ligase Ligand-Linker Conjugates 20	Thalidomide-O-amido-C8-NH2 (Cereblon Ligand-Linker Conjugates 2), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs.
DC47886	Thalidomide-Piperazine 5-fluoride	Thalidomide-Piperazine 5-fluoride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

(S,R,S)-AHPC-PEG4-NH2 hydrochloride