5-Hydroxy-1,4-naphthalenedione|cas 481-39-0|DC Chemicals

Cas No.:	481-39-0
SMILES:	OC1=CC=CC2C(C=CC(=O)C1=2)=O
Formula:	C₁₀H₆O₃
M.Wt:	174.15
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	Juglone is a yellow pigment found in black walnut (Juglans regia). Juglone also shows antimicrobial activity[1].
References:	[1]. J. Johnson Inbaraj, et al. Cytotoxic Action of Juglone and Plumbagin: A Mechanistic Study Using HaCaT Keratinocytes.Chem. Res. Toxicol. 2004, 17, 1, 55-62

Cat. No.	Product name	Field of application
DCH-057	Trigonelline	>98%,Standard References
DCW-004	Citric acid	Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice.
DCB-029	Anemoside B4	Pulchinenoside B4 is a triterpenoid glycoside that inhibits cisplatin-induced apoptosis, increases in reactive oxygen species (ROS) production, and decreases in superoxide dismutase (SOD) and catalase activities. Pulchinenoside B4 also prevents increases in plasma blood urea nitrogen (BUN) and creatinine levels -- markers of kidney injury.
DCG-043	Triolein	Triolein is a symmetric triacylglycerol that reduces upregulation of MMP-1 and has strong antioxidant and anti-inflammatory activities.
DCG-004	Glycyrrhizic acid	>98%,Standard References
DCF-003	Lycopene	>98%,Standard References
DCG-002	β-Sitosterol	β-Sitosterol is orally active. Beta-Sitosterol exhibits multiple activities, including anti-inflammatory, anticancer, antioxidant, antimicrobial, antidiabetic, antioxidant enzyme, and analgesic. Beta-Sitosterol inhibits inflammation and impaired adipogenesis in bovine mammary epithelial cells by reducing levels of ROS, TNF-α, IL-1β, and NF-κB p65 and restoring the activity of the HIF-1α/mTOR signaling pathway. Beta-Sitosterol induces apoptosis in cancer cells through ROS-mediated mitochondrial dysregulation and p53 activation. Beta-Sitosterol exerts its anticancer effects in cancer cells by activating caspase-3, caspase-8, and caspase-9, mediating PARP inactivation, MMP loss, altered Bcl-2-Bax ratio, and cytochrome c release. Beta-Sitosterol modulates macrophage polarization and reduces rheumatoid inflammation in mice. Beta-Sitosterol inhibits tumor growth in multiple mouse cancer models. Beta-Sitosterol can be used in the research of arthritis, lung cancer, breast cancer and other cancers, diabetes, etc.
DCD-042	Stigmasterol	Stigmasterol is an orally acitve, immunomodulatory agent with anti-inflammatory and neuroprotective effect, as well as able to cross the blood-brain barrier. Stigmasterol activates AMPK, which in turn inhibits NF-κB and NLRP3 signaling pathways, reduces microglia-mediated neuroinflammation, and alleviates cognitive impairment and Alzheimer's disease. Stigmasterol regulates M1/M2 polarization of microglia through the TLR4/ NF-κB pathway, thereby reducing neuropathic pain. Stigmasterol can be used for neurodegenerative diseases, inflammatory diseases, and pain management, among others.
DCT-004	Crustecdysone	Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP. Crustecdysone exhibits regulatory or protective roles in the cardiovascular system. Crustecdysone is an active metabolite of Ecdysone (HY-N0179).
DCN-014	Tauroursodeoxycholic acid	Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

5-Hydroxy-1,4-naphthalenedione(Juglone)