AZ3451|cas 2100284-59-9|DC Chemicals

Cas No.:	2100284-59-9
Chemical Name:	2-(6-Bromanyl-1,3-Benzodioxol-5-Yl)-~{n}-(4-Cyanophenyl)-1-[(1~{s})-1-Cyclohexylethyl]benzimidazole-5-Carboxamide
Synonyms:	2-(6-Bromo-1,3-benzodioxol-5-yl)-N-(4-cyanophenyl)-1-[(1S)-1-cyclohexylethyl]-1H-benzimidazole-5-carboxamide;AZ3451;(S)-2-(6-bromobenzo[d][1,3]dioxol-5-yl)-N-(4-cyanophenyl)-1-(1-cyclohexylethyl)-1H-benzo[d]imidazole-5-carboxamide;AZ 3451;2-(6-Bromanyl-1,3-Benzodioxol-5-Yl)-~{n}-(4-Cyanophenyl)-1-[(1~{s})-1-Cyclohexylethyl]benzimidazole-5-Carboxamide;(S)-2-(6-Bromobenzo[d][1,3]dioxol-5-yl)-N-(4-cyanophenyl)-1-(1-cyclohexylethyl)-1Hbenzo[d]imidazole-5-carboxamide;GTPL9560;BDBM50274114;s9744;2-(6-Bromo-1,3-benzodioxol-
SMILES:	BrC1=C([H])C2=C(C([H])=C1C1=NC3C([H])=C(C(N([H])C4C([H])=C([H])C(C#N)=C([H])C=4[H])=O)C([H])=C([H])C=3N1[C@@]([H])(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])OC([H])([H])O2
Formula:	C₃₀H₂₇BrN₄O₃
M.Wt:	571.4644
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	AZ3451 is a protease-activated receptor-2 (PAR2) antagonist.
In Vitro:	Antagonist AZ3451 binds to a remote allosteric site outside the helical bundle of the protease-activated receptor 2. AZ3451 is highly lipophilic, which coincides with the hydrophobic nature of the binding pocket within the membrane. Antagonist binding prevents structural rearrangements required for receptor activation and signalling[1].

Cat. No.	Product name	Field of application
DC8860	Vorapaxar	Vorapaxar (SCH 530348) is a potent and orally active thrombin receptor (PAR-1) antagonist with Ki of 8.1 nM.
DC7197	ML 161	Inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50 = 0.26 μM for the inhibition of platelet P-selectin expression on human platelets). Thought to act allosterically. Also inhibits thrombin-induced platelet activation.
DC11923	BMS-986120	BMS-986120 (BMS986120) is a potent, selective, orally bioavailable, and reversible PAR4 antagonist with Kd of 0.098 nM for human PAR4.
DC10879	AZ3451	AZ3451 is a potent and selective allosteric antagonist of protease-activated receptor 2 (PAR2)