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| Cas No.: | 1478712-37-6 |
| Chemical Name: | 2-methoxy-6-[6-methoxy-4-[[5-methyl-2-(4-morpholinyl)-4-thiazolyl]methoxy]-2-benzofuranyl]-imidazo[2,1-b]-1,3,4-thiadiazole |
| SMILES: | CC(SC(N1CCOCC1)=N2)=C2COC3=CC(OC)=CC4=C3C=C(O4)C5=CN6N=C(OC)SC6=N5 |
| Formula: | C23N5O5S2H23 |
| M.Wt: | 513.5892 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | BMS-986120 (BMS986120) is a potent, selective, orally bioavailable, and reversible PAR4 antagonist with Kd of 0.098 nM for human PAR4; selectivity inhibits PAR4 AP-induced cellular calcium mobilization in HEK cells with IC5o of 0.56 nM, with no activity on PAR1 and PAR2; inhibits human PRP aggregation in response to γ-thrombin in vitro with IC50 of 7.3 nM; demonstrates potent and highly efficacious antithrombotic activity with low bleeding in vivo. |