BAY-985 | TBK1/IKKε Inhibitor | CAS 2409479-29-2|DC Chemicals

Cas No.:	2409479-29-2
Chemical Name:	BAY985;BAY 985
Synonyms:	BAY985;BAY 985
SMILES:	O=C(CC(F)(F)F)N1CCN([C@H](C)C2C=CN=C(NC3NC4C(=CC=C(C=4)C4C=C(N(C)C)N=CN=4)N=3)C=2)CC1
Formula:	C₂₇H₃₀F₃N₉O
M.Wt:	553.58
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	[1]. Lefranc J, et al. Discovery of BAY-985, a Highly Selective TBK1/IKKε Inhibitor. J Med Chem. 2020 Jan 10.

Cat. No.	Product name	Field of application
DC71677	IMD-0560	IMD-0560 is an Inhibitor of nuclear factor kappa-B kinase (IKK) which can suppress the production of inflammatory cytokines and chemokines.
DC70227	AZ13102909	AZ13102909 (AZ909) is a potent and selrctive TBK1 inhibitor with IC50 of 5 nM, 100-1000 fold greater for other related kinases.AZ909 combines with AZD6244 to enhance apoptosis in AZD6244-resistant lines in 3D culture.
DC44511	NF-κB-IN-1	NF-κB-IN-1, a 4-arylidene crucumin analogue, is a potent NF-κB signaling pathway inhibitor. NF-κB-IN-1 directly inhibits IKK to block NF-κB activation. NF-κB-IN-1 effectively inhibits the viability of lung cancer cells and attenuates the clonogenic activity of A549 cells.
DC28732	BAY-985	BAY-985 is a highly potent, orally active and selective ATP-competitive dual inhibitor of TBK1 and IKKε with IC50s of 2/30 and 2 nM for TBK1 (low/high ATP) and IKKε, respectively. Antitumor efficacy.
DC7159	TPCA-1	TPCA-1 is potent, selective inhibitor of IKK-2 (IC50 = 17.9 nM) that displays>22-fold selectivity over IKK-1 and > 550-fold selectivity over other kinases and enzymes.
DC7969	PS-1145	PS-1145 has been shown to be an IKK (IKB kinase) inhibitor.
DC9484	IKK-2 inhibitor VIII	IKK-2 inhibitor VIII is a potent and selective IKK-2 inhibitor with IC50 of 8.5 nM.
DC11960	BI605906	BI605906 is a potent, specific IKKβ inhibitor with IC50 of 380 nM (0.1 mM ATP), does not suppress signaling downstream of mTOR or activate AMPK.