AZ13102909|CAS 2322365-47-7|DC Chemicals

Cas No.:	2322365-47-7
Chemical Name:	AZ13102909
Synonyms:	N-[3-[[6-Bromo-2-[4-[2-(1-piperidinyl)ethoxy]phenyl]-3H-imidazo[4,5-b]pyridin-7-yl]amino]propyl]cyclopentanecarboxamide
SMILES:	C1(C(NCCCNC2C(Br)=CN=C3NC(C4=CC=C(OCCN5CCCCC5)C=C4)=NC3=2)=O)CCCC1
Formula:	C₂₈H₃₇BrN₆O₂
M.Wt:	569.536385297775
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Cat. No.	Product name	Field of application
DC71677	IMD-0560	IMD-0560 is an Inhibitor of nuclear factor kappa-B kinase (IKK) which can suppress the production of inflammatory cytokines and chemokines.
DC70227	AZ13102909	AZ13102909 (AZ909) is a potent and selrctive TBK1 inhibitor with IC50 of 5 nM, 100-1000 fold greater for other related kinases.AZ909 combines with AZD6244 to enhance apoptosis in AZD6244-resistant lines in 3D culture.
DC44511	NF-κB-IN-1	NF-κB-IN-1, a 4-arylidene crucumin analogue, is a potent NF-κB signaling pathway inhibitor. NF-κB-IN-1 directly inhibits IKK to block NF-κB activation. NF-κB-IN-1 effectively inhibits the viability of lung cancer cells and attenuates the clonogenic activity of A549 cells.
DC28732	BAY-985	BAY-985 is a highly potent, orally active and selective ATP-competitive dual inhibitor of TBK1 and IKKε with IC50s of 2/30 and 2 nM for TBK1 (low/high ATP) and IKKε, respectively. Antitumor efficacy.
DC7159	TPCA-1	TPCA-1 is potent, selective inhibitor of IKK-2 (IC50 = 17.9 nM) that displays>22-fold selectivity over IKK-1 and > 550-fold selectivity over other kinases and enzymes.
DC7969	PS-1145	PS-1145 has been shown to be an IKK (IKB kinase) inhibitor.
DC9484	IKK-2 inhibitor VIII	IKK-2 inhibitor VIII is a potent and selective IKK-2 inhibitor with IC50 of 8.5 nM.
DC11960	BI605906	BI605906 is a potent, specific IKKβ inhibitor with IC50 of 380 nM (0.1 mM ATP), does not suppress signaling downstream of mTOR or activate AMPK.