CFTR Inhibitor II|cas 328541-79-3|DC Chemicals

Cas No.:	328541-79-3
Chemical Name:	Glycine, N-2-naphthalenyl-, [(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide
Synonyms:	Glycine, N-2-naphthalenyl-, [(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide;N-2-Naphthalenyl-glycine 2-[(3,5-Dibromo-2,4-dihydroxyphenyl)methylene]hydrazide;CFTR Inhibitor II;CFTR Inhibitor II, GlyH-101;GLYH 101;GlyH-101;N'-[(3,5-dibromo-4-hydroxy-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]-2-(naphthalen-2-ylamino)acetohydrazide;N-2-Naphthalenyl-gly;N-2-Naphthalenylglycine [(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide
SMILES:	O=C(N/N=C/C1=CC(Br)=C(O)C(Br)=C1O)CNC2=CC3=CC=CC=C3C=C2
Formula:	C₁₉H₁₅N₃O₃Br₂
M.Wt:	493.1487
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM.

Cat. No.	Product name	Field of application
DC1059	Lumacaftor(vx-809，vx809)	VX-809 is a CFTR modulator with EC50 of 0.1 μM.
DC7531	Tezacaftor(VX661)	Tezacaftor(VX661) is a second F508del CFTR corrector and is believed to help CFTR protein reach the cell surface.
DC7100	CFTRinh 172	Voltage-independent, selective CFTR chloride channel blocker (Ki = 300 nM) that alters channel gating.
DC7483	PPQ-102	PPQ-102 is a potent CFTR inhibitor which can completely inhibited CFTR chloride current with IC 50approximately 90 nM.
DC9276	KM 11060	KM 11060 corrects F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasma membrane (~75%) and Inhibits PDE5 activity.
DC4128	Ivacaftor (VX-770)	Ivacaftor (VX-770, Kalydeco) is a potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM, respectively.
DC10753	GLPG-1837(ABBV-974)	GLPG-1837(ABBV-974) is a novel cystic fibrosis transmembrane conductance regulator CFTR potentiator.
DC7039	CFTR Inhibitor II	CFTR Inhibitor II is a cell-permeable glycinyl hydrazone compound that acts as a potent, selective and reversible open-channel blocker of CFTR with intermediate speed (< 1 min; 95% inhibition at 50 µM; Ki = 4.3 µM in CFTR-expressing FRT cells.