Tezacaftor(VX661)|cas 1152311-62-0|VX-661

Cas No.:	1152311-62-0
Chemical Name:	Cyclopropanecarboxamide, 1-(2,2-difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(2-hydroxy-1,1-dimethylethyl)-1H-indol-5-yl]-
Synonyms:	VX 661; VX661,VX-661
SMILES:	C(C1=CC=C2OC(F)(F)OC2=C1)(C(NC1C(F)=CC2=C(C=1)C=C(C(C)(C)CO)N2C[C@H](O)CO)=O)1CC1
Formula:	C₂₆H₂₇F₃N₂O₆
M.Wt:	520.5
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	VX-661 is a second F508del CFTR corrector and help CFTR protein reach the cell surface.
In Vitro:	In vitro, a combination of VX-661 and ivacaftor results in greater CFTR activity compared with VX-661 alone[2].

Cat. No.	Product name	Field of application
DC1059	Lumacaftor(vx-809，vx809)	VX-809 is a CFTR modulator with EC50 of 0.1 μM.
DC7531	Tezacaftor(VX661)	Tezacaftor(VX661) is a second F508del CFTR corrector and is believed to help CFTR protein reach the cell surface.
DC7100	CFTRinh 172	Voltage-independent, selective CFTR chloride channel blocker (Ki = 300 nM) that alters channel gating.
DC7483	PPQ-102	PPQ-102 is a potent CFTR inhibitor which can completely inhibited CFTR chloride current with IC 50approximately 90 nM.
DC9276	KM 11060	KM 11060 corrects F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasma membrane (~75%) and Inhibits PDE5 activity.
DC4128	Ivacaftor (VX-770)	Ivacaftor (VX-770, Kalydeco) is a potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM, respectively.
DC10753	GLPG-1837(ABBV-974)	GLPG-1837(ABBV-974) is a novel cystic fibrosis transmembrane conductance regulator CFTR potentiator.
DC7039	CFTR Inhibitor II	CFTR Inhibitor II is a cell-permeable glycinyl hydrazone compound that acts as a potent, selective and reversible open-channel blocker of CFTR with intermediate speed (< 1 min; 95% inhibition at 50 µM; Ki = 4.3 µM in CFTR-expressing FRT cells.