Cot inhibitor-2|cas 915363-56-3|DC Chemicals

Cas No.:	915363-56-3
Synonyms:	3-Quinolinecarbonitrile, 8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-(1-ethyl-4-piperidinyl)-1H-1,2,3-triazol-4-yl]methyl]amino]-
SMILES:	N#CC1=C(C2=CC(NCC3=CN(N=N3)C4CCN(CC4)CC)=CC(Cl)=C2N=C1)NC5=CC=C(F)C(Cl)=C5
Formula:	C₂₆H₂₅Cl₂FN₈
M.Wt:	539.4347
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Cot inhibitor-2 is a COT/Tpl2 inhibitor.

Cat. No.	Product name	Field of application
DC11036	TCASK10	TCASK10 is a potent, highly specific inhibitor of ASK1 with IC50 of 14 nM, 30-fold selectivity over ASK2 (IC50=510 nM) and no activity against MEKK1, TAK1, IKKβ, ERK1, JNK1, p38α, GSK-3β, PKCθ and B-raf.
DC9555	Cot inhibitor-2	Cot inhibitor-2 is a COT/Tpl2 inhibitor.
DC11558	DLK-IN-14	A potent, selective, CNS penetrant dual leucine zipper kinase (DLK, MAP3K12) inhibitor with Ki of 3 nM.
DC11610	AKS1-IN-19	A novel potent, selective and orally active ASK1 (MAP3K5) inhibitor with pIC50 of 8.3.
DC11622	MAP3K14-IN-173	A novel potent MAP3K14 kinase inhibitor with IC50 of 1.8 nM (NIK autophosphorylation).