STING inhibitor C-176|

Cas No.:	314054-00-7
Chemical Name:	N-(4-iodophenyl)-5-nitrofuran-2-carboxamide
SMILES:	O1C([N+]([O-])=O)=CC=C1C(NC1=CC=C(I)C=C1)=O
Formula:	C₁₁H₇In₂O₄
M.Wt:	358.091
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	C-176 is a strong and covalent mouse STING inhibitor.
In Vivo:	Notably, treatment of Trex1−/− mice with C-176 resulted in a significant reduction in serum levels of type I IFNs and in a strong suppression of inflammatory parameters in the heart. Wild-type mice on a two-week treatment with C-176 show no evident signs of overt toxicity. We next conducted a three-month trial with C-176 in Trex1−/− mice, which demonstrated marked amelioration of various signs of systemic inflammation[1].
In Vitro:	C-176 strongly reduces STING-mediated, but not RIG-I- or TBK1-mediated, IFNβ reporter activity. Pretreatment with C-176 markedly reduce the CMA-mediated induction of serum levels of type I IFNs and IL-6[1].

Cat. No.	Product name	Field of application
DC28013	Cyclic-di-GMP(c-di-GMP)	Cyclic di-GMP (c-di-GMP) is one of the most important and common bacterial second messenger. It is involved in numerous prokaryotic processes, including biofilm formation, motility, virulence, and cell cycling. c-di-GMP also has functions in eukaryotic cells. It is detected by the transmembrane protein stimulator of interferon genes (STING), leading to activation of the innate immune system.
DC28012	c-Di-AMP(Cyclic-Di-AMP) ammonium salt	Bis-(3'-5')-cyclic dimeric adenosine monophosphate (c-di-AMP) is a bacterial second messenger implicated in the control of cell wall metabolism, osmotic stress responses and sporulation. Detection of c-di-AMP by the host cytoplasmic surveillance pathway (CSP) is known to elicit type I IFN responses through a signaling axis that involves STING, TBK1 and IRF3 [1, 2]. Involvement of the helicase DDX41 in the recognition of c-di-AMP has been suggested [3]. Recent studies have also demonstrated that c-di-AMP exerts strong adjuvant activities when delivered by the mucosal route [4, 5].
DC10959	STING inhibitor C-178	STING inhibitor C-178 is a covalent, small-molecule inhibitor of STING, blocks palmitoylation (PMA)-induced clustering of STING; covalently binds to Cys91, directly targets mouse STING (mmSTING) but not human STING (hsSTING).
DC10960	STING inhibitor C-176	STING inhibitor C-178 is a covalent, in vivo-active, small-molecule inhibitor of STING
DC10908	ML RR-S2 CDA	ML RR-S2 CDA is a synthetic cyclic dinucleotide (CDN) that contains non-canonical 2'5'-phosphodiester bonds and is an activator of stimulator of interferon genes (STING).
DC10876	H-151	H-151(H151) is a novel STING (stimulator of interferon genes) antagonist.
DC12321	STING agonist-1 trihydrochloride	diABZI STING agonist-1 (trihydrochloride) is a selective stimulator of interferon genes (STING) receptor agonist.
DC11642	Cridanimod sodium	Cridanimod sodium is a potent type I interferon (IFN) inducer that directly binds to STING and triggers a strong antiviral response through the TBK1/IRF3 route.
DC11641	Cridanimod	A potent type I interferon (IFN) inducer that directly binds to STING and triggers a strong antiviral response through the TBK1/IRF3 route.
DC12367	Cyclic guanosine monophosphate-adenosine monophosphate	2'3'-cGAMP has been used to identify small compounds capable of binding human stimulator of interferon genes (STING). It is also used to study type I interferon response to cytosolic DNA.