Cyclic di-AMP(c-di-AMP)|CAS 54447-84-6|STING research

Cas No.:	54447-84-6
Synonyms:	Cyclic di-3',5'-adenylate;c-Di-AMP;Cyclic-di-AMP;Cyclic diadenylate;Cyclic di-AMP;Cyclic di-AMP
SMILES:	NC1=NC=NC2N([C@@H]3O[C@@H]4COP(O[C@@H]5[C@@H](COP(O[C@H]4[C@H]3O)(O)=O)O[C@@H](N3C=NC4C(=NC=NC3=4)N)[C@@H]5O)(O)=O)C=NC1=2
Formula:	C₂₀H₂₄N₁₀O₁₂P₂
M.Wt:	658.41
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	Cyclic-di-AMP (c-di-AMP) is a second messenger molecule produced in bacteria but not in mammals; can induce a strong immune response in vitro and in vivo.
References:	[1]. Ren A, et al. c-di-AMP binds the ydaO riboswitch in two pseudo-symmetry-related pockets. Nat Chem Biol. 2014 Sep;10(9):780-6.

Cat. No.	Product name	Field of application
DC28013	Cyclic-di-GMP(c-di-GMP)	Cyclic di-GMP (c-di-GMP) is one of the most important and common bacterial second messenger. It is involved in numerous prokaryotic processes, including biofilm formation, motility, virulence, and cell cycling. c-di-GMP also has functions in eukaryotic cells. It is detected by the transmembrane protein stimulator of interferon genes (STING), leading to activation of the innate immune system.
DC28012	c-Di-AMP(Cyclic-Di-AMP) ammonium salt	Bis-(3'-5')-cyclic dimeric adenosine monophosphate (c-di-AMP) is a bacterial second messenger implicated in the control of cell wall metabolism, osmotic stress responses and sporulation. Detection of c-di-AMP by the host cytoplasmic surveillance pathway (CSP) is known to elicit type I IFN responses through a signaling axis that involves STING, TBK1 and IRF3 [1, 2]. Involvement of the helicase DDX41 in the recognition of c-di-AMP has been suggested [3]. Recent studies have also demonstrated that c-di-AMP exerts strong adjuvant activities when delivered by the mucosal route [4, 5].
DC10959	STING inhibitor C-178	STING inhibitor C-178 is a covalent, small-molecule inhibitor of STING, blocks palmitoylation (PMA)-induced clustering of STING; covalently binds to Cys91, directly targets mouse STING (mmSTING) but not human STING (hsSTING).
DC10960	STING inhibitor C-176	STING inhibitor C-178 is a covalent, in vivo-active, small-molecule inhibitor of STING
DC10908	ML RR-S2 CDA	ML RR-S2 CDA is a synthetic cyclic dinucleotide (CDN) that contains non-canonical 2'5'-phosphodiester bonds and is an activator of stimulator of interferon genes (STING).
DC10876	H-151	H-151(H151) is a novel STING (stimulator of interferon genes) antagonist.
DC12321	STING agonist-1 trihydrochloride	diABZI STING agonist-1 (trihydrochloride) is a selective stimulator of interferon genes (STING) receptor agonist.
DC11642	Cridanimod sodium	Cridanimod sodium is a potent type I interferon (IFN) inducer that directly binds to STING and triggers a strong antiviral response through the TBK1/IRF3 route.
DC11641	Cridanimod	A potent type I interferon (IFN) inducer that directly binds to STING and triggers a strong antiviral response through the TBK1/IRF3 route.
DC12367	Cyclic guanosine monophosphate-adenosine monophosphate	2'3'-cGAMP has been used to identify small compounds capable of binding human stimulator of interferon genes (STING). It is also used to study type I interferon response to cytosolic DNA.

c-Di-AMP(Cyclic-Di-AMP) ammonium salt